Journal of Food and Nutrition Research
ISSN (Print): 2333-1119 ISSN (Online): 2333-1240 Website: http://www.sciepub.com/journal/jfnr Editor-in-chief: Prabhat Kumar Mandal
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Journal of Food and Nutrition Research. 2017, 5(8), 594-605
DOI: 10.12691/jfnr-5-8-10
Open AccessArticle

Comparison of Anti-obesity Effects of Spirit Vinegar and Natural Fermented Vinegar Products on the Differentiation of 3T3-L1 Cells and Obese Rats Fed a High-fat Diet

Hee-Kyoung Son1, Yeon-Kyoung Kim1, Hye Won Shin2, Hee Jeong Lim2, Byoung-Seok Moon2 and Jae-Joon Lee1,

1Department of Food and Nutrition, Chosun University, Gwangju, Korea

2Foods Research Institute, CJ Cheil Jedang Corp., Suwon, Korea

Pub. Date: July 29, 2017

Cite this paper:
Hee-Kyoung Son, Yeon-Kyoung Kim, Hye Won Shin, Hee Jeong Lim, Byoung-Seok Moon and Jae-Joon Lee. Comparison of Anti-obesity Effects of Spirit Vinegar and Natural Fermented Vinegar Products on the Differentiation of 3T3-L1 Cells and Obese Rats Fed a High-fat Diet. Journal of Food and Nutrition Research. 2017; 5(8):594-605. doi: 10.12691/jfnr-5-8-10

Abstract

This study aimed to compare the effects of spirit vinegar and four types of natural fermented vinegar products (apple vinegar, brown rice vinegar, lemon vinegar, and balsamic vinegar) on the differentiation of 3T3-L1 cells and obesity in rats fed a high-fat diet (HFD). Vinegar inhibited the accumulation of lipid droplets during the differentiation of 3T3-L1 cells. Body weight gains, visceral fat pad weights, serum leptin and triglyceride levels, and hepatic lipogenic enzyme mRNA levels were significantly decreased in the HF-vinegar administered groups compared with those in the HF group. Furthermore, oral administration of vinegars significantly reduced the occurrence of fatty liver deposits and steatosis, and inhibited the HF diet-induced increase in adipocyte size. The anti-obesity and lipid-lowering effects were slightly greater in the HF-natural fermented vinegar groups than in the HF-spirit vinegar group. Apple vinegar had the strongest anti-obesity effects in 3T3-L1 cells and obese rats compared with the other tested vinegars. These findings indicated that vinegar administration may have potential for improving some obesity-related parameters in 3T3-L1 cells and obese rats.

Keywords:
natural fermented vinegar spirit vinegar 3T3-L1 cells differentiation high-fat diet anti-obesity

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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