Journal of Food and Nutrition Research
ISSN (Print): 2333-1119 ISSN (Online): 2333-1240 Website: http://www.sciepub.com/journal/jfnr Editor-in-chief: Prabhat Kumar Mandal
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Journal of Food and Nutrition Research. 2020, 8(6), 273-278
DOI: 10.12691/jfnr-8-6-5
Open AccessReview Article

Evaluation in Patients with High NORMAL Blood Pressure of a Supplement Containing Arginine, Lactobacillus Plantarum Lp-LDL, Coenzime Q10 and Vitamin B1: A PILOT Study

Giuseppe Derosa1, 2, , Giovanni Gaudio3, Angela D’Angelo1, 4 and Pamela Maffioli1

1Department of Internal Medicine and Therapeutics, University of Pavia, PAVIA, Italy

2Laboratory of Molecular Medicine, University of Pavia, PAVIA, Italy;Responsible Diabetes Area of Italian Nutraceutical Society (SINut)

3Internal Medicine Division, Ospedale Angelo Bellini, Somma Lombardo, VARESE, Italy

4Laboratory of Molecular Medicine, University of Pavia, PAVIA, Italy

Pub. Date: July 15, 2020

Cite this paper:
Giuseppe Derosa, Giovanni Gaudio, Angela D’Angelo and Pamela Maffioli. Evaluation in Patients with High NORMAL Blood Pressure of a Supplement Containing Arginine, Lactobacillus Plantarum Lp-LDL, Coenzime Q10 and Vitamin B1: A PILOT Study. Journal of Food and Nutrition Research. 2020; 8(6):273-278. doi: 10.12691/jfnr-8-6-5

Abstract

Aim: to evaluate the effects of a nutraceutical containing Arginine, Lactobacillus Plantarum Lp-LDL, Coenzyme Q10 and Vitamin B1 in patients with high normal blood pressure on the levels of systolic (SBP) and diastolic blood pressure (DBP). Methods: we enrolled 40 patients of both sexes, with high normal pressure (SBP values between 130-139 mmHg and/or DBP between 85-89 mmHg) according to the 2018 ESC/ESH Guidelines for the management of arterial hypertension. Patients were consecutively enrolled to take nutraceutical for 3 months and it is self-administered once a day during the breakfast. Results: no significant variations of BMI or circumferences were recorded with nutraceutical from baseline. A slight reduction of FPG was recorded, although this variation was not significant. Significant reductions were obtained in SBP (p< 0.05) and DBP (p< 0.05). No significant HR variation was observed from baseline. A significant TC and LDL-C decrease were observed after 3 months (p< 0.05, respectively). No significant HDL-C, and Tg variations were obtained after 3 months. No significant reduction of Hs-CRP was recorded compared to baseline. No significant variations of transaminases were recorded during the study, and creatinine value was not significantly modified compared to baseline. Conclusions: a nutraceutical containing Arginine, Lactobacillus Plantarum Lp-LDL, Coenzyme Q10 and Vitamin B1 could be helpful in improving high normal blood pressure, and hypercholesterolemia, two of the major risk factors for vascular events.

Keywords:
arginine Lactobacillus Plantarum Lp-LDL Coenzime Q10 Vitamin B1 blood pressure

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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