Giuseppe Derosa^{1, 2,}, Giovanni Gaudio³, Angela D’Angelo^{1, 4}, Pamela Maffioli¹

Aim: to evaluate the effects of a nutraceutical containing Arginine, Lactobacillus Plantarum Lp-LDL, Coenzyme Q10 and Vitamin B1 in patients with high normal blood pressure on the levels of systolic (SBP) and diastolic blood pressure (DBP). Methods: we enrolled 40 patients of both sexes, with high normal pressure (SBP values between 130-139 mmHg and/or DBP between 85-89 mmHg) according to the 2018 ESC/ESH Guidelines for the management of arterial hypertension. Patients were consecutively enrolled to take nutraceutical for 3 months and it is self-administered once a day during the breakfast. Results: no significant variations of BMI or circumferences were recorded with nutraceutical from baseline. A slight reduction of FPG was recorded, although this variation was not significant. Significant reductions were obtained in SBP (p< 0.05) and DBP (p< 0.05). No significant HR variation was observed from baseline. A significant TC and LDL-C decrease were observed after 3 months (p< 0.05, respectively). No significant HDL-C, and Tg variations were obtained after 3 months. No significant reduction of Hs-CRP was recorded compared to baseline. No significant variations of transaminases were recorded during the study, and creatinine value was not significantly modified compared to baseline. Conclusions: a nutraceutical containing Arginine, Lactobacillus Plantarum Lp-LDL, Coenzyme Q10 and Vitamin B1 could be helpful in improving high normal blood pressure, and hypercholesterolemia, two of the major risk factors for vascular events.

arginine, Lactobacillus Plantarum Lp-LDL, Coenzime Q10, Vitamin B1, blood pressure