Journal of Food and Nutrition Research
ISSN (Print): 2333-1119 ISSN (Online): 2333-1240 Website: Editor-in-chief: Prabhat Kumar Mandal
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Journal of Food and Nutrition Research. 2017, 5(9), 636-641
DOI: 10.12691/jfnr-5-9-2
Open AccessArticle

Food Supplements Were Applied to the Mitochondrial Capacity of Retinal Cells and Oxidative Phosphorylation of Adenosine Triphosphate (ATP) Synthesis

Shun-Chieh Yang1, Chi-Tang Tu1, Han-Chung Cheng1, Ying-Chieh Lai2 and Shou-Jen Lan2, 3,

1Taiwan Mitochondrion Applied Technology Co..Ltd, Taiwan

2Department of Healthcare Administration, Asia University, Taiwan

3Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan

Pub. Date: August 09, 2017

Cite this paper:
Shun-Chieh Yang, Chi-Tang Tu, Han-Chung Cheng, Ying-Chieh Lai and Shou-Jen Lan. Food Supplements Were Applied to the Mitochondrial Capacity of Retinal Cells and Oxidative Phosphorylation of Adenosine Triphosphate (ATP) Synthesis. Journal of Food and Nutrition Research. 2017; 5(9):636-641. doi: 10.12691/jfnr-5-9-2


The retina consists of many different cells, the most important of which are retinal cells. Retinal cells have a lot of mitochondria. The mitochondria in retinal cells provide the energy of retinal cell activity, including the energy required to convert light into nerve signals. However, when the sun enters the eye and is irradiated on the retina, the high-energy ultraviolet light in the solar energy causes the mitochondria in the retinal cells and retinal cells to produce free radicals. These free radicals are detrimental to retinal cells and mitochondrial intima. Long-term accumulation, in addition to free radicals directly to the damage caused by retinal cells, the serious damage to the mitochondrial intima can also cause mitochondrial decomposition, and then lead to retinal cell apoptosis. This study discloses an eye care method comprising the provision of Phyllanthus emblica extract for the use of retinal cells in the late stage of ultraviolet or ultraviolet irradiation to obtain mitochondria in retinal cells of chlorophyll extract for oxidative phosphoric acid (ATP) synthesis Higher than the mitochondria, without Phyllanthus emblica extract of retinal cells, and with triphosphate (ATP) for phosphorylation. According to the above method, the supply of Phyllanthus emblica extract retinal cells protects the inner membrane of mitochondria in retinal cells, thereby delaying the decomposition time of mitochondria, adding Phyllanthus emblica extract can also reduce the free radical content of retinal cells such as bamboo leaf extract can slow Mitotic decomposition caused by the rate of apoptosis and can reduce the effectiveness of retinal cells due to excessive free radical content and damage to protect retinal cells to achieve eye care.

Phyllanthus emblicas retinal cell mitochondria ATP

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[1]  Chan, C.M., et al., Protective effects of resveratrol against UVA-induced damage in ARPE19 cells. Int J Mol Sci, 2015. 16(3): p. 5789-802.
[2]  Bruce A. Berkowitz, 2 Bryce X. Bredell,1 Christopher Davis,1 Marijana Samardzija,3 and a.R.R. Christian Grimm, Measuring In Vivo Free Radical Production by the Outer Retina. Investigative Ophthalmology & Visual Science, 2015.
[3]  Kataoka, T., Study of antioxidative effects and anti-inflammatory effects in mice due to low-dose X-irradiation or radon inhalation. J Radiat Res, 2013. 54(4): p. 587-96.
[4]  Bergman, O. and D. Ben-Shachar, Mitochondrial Oxidative Phosphorylation System (OXPHOS) Deficits in Schizophrenia: Possible Interactions with Cellular Processes. Can J Psychiatry, 2016. 61(8): p. 457-69.
[5]  Bruce A. Berkowitz, Timothy S. Kern, David Bissig, Priya Patel, Ankit Bhatia, and a. R.R. Vladimir J. Kefalov, Systemic Retinaldehyde Treatment Corrects Retinal Oxidative Stress, Rod Dysfunction, and Impaired VisualPerformance in Diabetic Mice. The Association for Research in Vision and Ophthalmology, Inc., 2015.
[6]  den Hollander, A.I., et al., Lighting a candle in the dark: advances in genetics and gene therapy of recessive retinal dystrophies. J Clin Invest, 2010. 120(9): p. 3042-53.
[7]  Hoon, M., et al., Functional architecture of the retina: development and disease. Prog Retin Eye Res, 2014. 42: p. 44-84.
[8]  Kohno, H., et al., Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal. J Biol Chem, 2013. 288(21): p. 15326-41.
[10]  Perusek, L. and T. Maeda, Vitamin A derivatives as treatment options for retinal degenerative diseases. Nutrients, 2013. 5(7): p. 2646-66.
[11]  Phaniendra, A., D.B. Jestadi, and L. Periyasamy, Free radicals: properties, sources, targets, and their implication in various diseases. Indian J Clin Biochem, 2015. 30(1): p. 11-26.
[12]  Seiji Hayashi, S.-i.I., Guey-Shuang Wu, Won R Wee, Narsing A Rao, and P.J. McDonnell, Oxygen free radical damage in the cornea after excimer laser therapy. British Journal of Ophthalmology 1996: p. 141-144.
[13]  Tang, P.H., et al., Effective and sustained delivery of hydrophobic retinoids to photoreceptors. Invest Ophthalmol Vis Sci, 2010. 51(11): p. 5958-64.
[14]  Usharani, P., N. Fatima, and N. Muralidhar, Effects of Phyllanthus emblica extract on endothelial dysfunction and biomarkers of oxidative stress in patients with type 2 diabetes mellitus: a randomized, double-blind, controlled study. Diabetes Metab Syndr Obes, 2013. 6: p. 275-84.
[15]  V. Lobo, A.P., [...], and N. Chandra, Free radicals, antioxidants and functional foods_ Impact on human health. Pharmacognosy Reviews, 2010: p. 118-126.
[16]  Xinxian Zhu, J.W., Polyphenol extract of Phyllanthus emblica (PEEP) induces inhibition of cell proliferation and triggers apoptosis in cervical cancer cells. Zhu et al. European Journal of Medical Research, 2013.