World Journal of Chemical Education
ISSN (Print): 2375-1665 ISSN (Online): 2375-1657 Website: Editor-in-chief: Prof. V. Jagannadham
Open Access
Journal Browser
World Journal of Chemical Education. 2024, 12(1), 39-44
DOI: 10.12691/wjce-12-1-6
Open AccessArticle

Creating CDIO-Based Chemistry Research Activities for Students: A Case Study in Organic Compound Structure

Cao Cu Giac1, , Pham Ngoc Tuan2 and Le Thi Thu Hiep1

1Vinh University, Vinh City, Vietnam

2Nguyen Thi Minh Khai High School, Ho Chi Minh City, Vietnam

Pub. Date: March 19, 2024

Cite this paper:
Cao Cu Giac, Pham Ngoc Tuan and Le Thi Thu Hiep. Creating CDIO-Based Chemistry Research Activities for Students: A Case Study in Organic Compound Structure. World Journal of Chemical Education. 2024; 12(1):39-44. doi: 10.12691/wjce-12-1-6


The chemistry program in university includes content on reaction mechanisms and IR and NMR spectroscopy. However, the laboratory conditions are limited, so students do not have access to experimental spectral data. Applying the CDIO teaching process, we designed a group activity for university students to help them improve their knowledge and ability to predict reaction mechanisms as well as use spectroscopy to confirm structures of predicted products. On that basis, there will be impact assessments on students' capacity when researching the structure of organic compounds in chemistry to take appropriate improvement measures. This activity uses spectral analysis and reaction mechanisms in an exercise. Students are tasked with predicting the reaction mechanism to identify the products of an organic chain reaction. Then, they analyze the provided IR and 1H NMR spectra and match each spectrum with the appropriate product.

CDIO organic compound structure reaction mechanisms NMR Spectroscopy IR Spectroscopy

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit


Figure of 7


[1]  E. Crawley, J. Malmqvist, S. Ostlund, D. Brodeur, Rethinking Engineering Education: The CDIO Approach, Springer.
[2]  Svante Gunnarsson, et. al., “Large Scale Use of The CDIO Syllabus In Formulation of Program and Course Goals”, Proceedings of the 3rd International CDIO Conference, MIT, Cambridge, Massachusetts, June 11-14, 2007.
[3], accessed May 2022.
[4]  Soulsby, D.; Wallner, A. S. Introduction to NMR Spectroscopy in the Undergraduate Curriculum. In NMR Spectroscopy in the Undergraduate Curriculum: First-Year and Organic Chemistry Courses Volume 2; Soulsby, D., Wallner, A.S., Eds.; ACS Symposium Series, American Chemical Society: Washington, DC, 2016; pp 1–10.
[5]  National Research Council. How People Learn: Brain, Mind, Experience, and School: Expanded Edition; National Academies Press: Washington, DC, 2000.
[6]  Karpicke, J. D.; Roediger, H. L. The Critical Importance of Retrieval for Learning. Science 2008, 319 (5865), 966–968.
[7]  Rocks, S. S.; Stockland, R. A. NMR Structure Elucidation in the Presence of Heteroatoms: An In-Class Activity. J. Chem. Educ. 2020, 97 (2), 479–483.
[8]  Nückles, M.; Hübner, S.; Renkl, A. Enhancing Self-Regulated Learning by Writing Learning Protocols. Learn. Instr. 2009, 19 (3), 259–271.
[9]  Conner, L. N. Cueing Metacognition to Improve Researching and Essay Writing in a Final Year High School Biology Class. Res. Sci. Educ. 2007, 37 (1), 1–16.
[10]  Berthold, K.; Nückles, M.; Renkl, A. Do Learning Protocols Support Learning Strategies and Outcomes? The Role of Cognitive and Metacognitive Prompts. Learn. Instr. 2007, 17 (5), 564–577.
[11]  Joshi, S. D.; Vagdevi, H. M.; Vaidya, V. P.; Gadaginamath, G. S. Synthesis of New 4-Pyrrol-1-yl Benzoic Acid Hydrazide Analogs and Some Derived Oxadiazole, Triazole and Pyrrole Ring Systems: A Novel Class of Potential Antibacterial and Antitubercular Agents. Eur. J. Med. Chem. 2008, 43 (9), 1989–1996.
[12]  Joshi, D. G.; Oza, H. B.; Parekh, Η. H. Synthesis of Some Novel 1,3,4-Oxadlazoles and 5-Oxo-Imidazolines as Potent Biologically Active Agents. Heterocycl. Commun. 1997, 3 (2), 169–174.
[13]  Burcu Arslan, N.; Özdemir, N.; Dayan, O.; Dege, N.; Koparır, M.; Koparır, P.; Muğlu, H. Direct and Solvent-Assisted Thione–Thiol Tautomerism in 5-(Thiophen-2-yl)-1,3,4-Oxadiazole-2(3H)-Thione: Experimental and Molecular Modeling Study. Chem. Phys. 2014, 439, 1–11.
[14]  Levit, M. H. Spin Dynamics: Basics of Nuclear Magnetic Resonance, 2nd ed.; John Wiley & Sons Ltd.: West Sussex, England, 2008.
[15]  Haynes, W. Student’s t-Test. Encyclopedia of Systems Biology. 2013, 2023–2025.
[16]  Cohen, J. Statistical Power Analysis for the Behavioral Sciences, 2nd ed.; Lawrence Earlbaum Associates: Hillsdale, NJ, 1988.
[17]  Levene, H. Robust Tests for Equality of Variances. In Contributions to Probability and Statistics: Essays in Honor of Harold Hotelling; Olkin, I., Ghurye, S.G., Hoeffding, W., Madow, W.G., Mann, H.B., Eds.; Stanford University Press: Stanford, CA, 1963; pp 62–62.