Anti-Obesity Effect of Proanthocyanidins from the Coat of Scarlet Runner Beans on High-Fat Diet-Fed Mice

Zhaohong Ci^{1, 2}, Chengyu Jiang^{1, 2}, Shuo Feng^{1, 2}, Shan Wu^{1, 2}, Yang Cui¹, Yuki Sasaki¹ and Michiyuki Kojima^{2, 3,}

¹Department of Food Production Science, Obihiro University of Agriculture and Veterinary Medicine, 11, Nishi-2-sen, Inada-machi, Obihiro, Hokkaido 080-8555, Japan

²United Graduate School of Agricultural Sciences, Iwate University, 3-18-8, Ueda, Morioka, Iwate 020-8550, Japan

³Department of Human Sciences, Obihiro University of Agriculture and Veterinary Medicine, 11, Nishi-2-sen, Inada-machi, Obihiro, Hokkaido 080-8555, Japan

Cite this paper:
Zhaohong Ci, Chengyu Jiang, Shuo Feng, Shan Wu, Yang Cui, Yuki Sasaki and Michiyuki Kojima. Anti-Obesity Effect of Proanthocyanidins from the Coat of Scarlet Runner Beans on High-Fat Diet-Fed Mice. Journal of Food and Nutrition Research. 2018; 6(2):103-109. doi: 10.12691/jfnr-6-2-6

Abstract

Proanthocyanidins are oligomeric or polymeric flavonoids found in several plants. They can be classified into two subgroups, namely A- and B-type proanthocyanidins. The coat of scarlet runner beans contains abundant proanthocyanidins (SRPAs) of the B-type configuration. To evaluate the efficacy of SRPAs as anti-obesity agents, we first examined their effect on lipase activity in vitro and found that they are potent inhibitors of this enzyme. Subsequently, we examined their effect on mice fed a high-fat diet. Male mice were assigned to the following seven-subject dietary groups: (1) high-fat diet; (2) high-fat diet supplemented with 0.5% SRPAs; (3) high-fat diet supplemented with 1.0% SRPAs, and; (4) standard chow for 15 weeks. SRPA supplementation decreased body weight gain; liver and kidney weight; perirenal, peritesticular, and periintestinal fat content; liver cholesterol level, and; serum neutral lipid and cholesterol levels. In contrast, the faecal lipid content and the liver anti-oxidative capacity increased. These findings suggest a potential use of SRPAs as a dietary supplement exerting anti-obesity effects through the inhibition of fat digestive enzymes.

Keywords:
scarlet runner bean coat anti-obesity proanthocyanidin lipase activity inhibition fat digestion

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