Dose Water Extract of Cinnamon (Cinnamomum Zeylanicum) Exhibits Anti-Diabetic Properties in Cultured 3T3-L1 Adipocytes: A Concurrent Assessment of Adipogenesis, Lipolysis and Glucose Uptakes

Nuraniza Azahari¹, Muhammad Muzaffar Ali Khan Khattak^{1, 2,} , Muhammad Taher^{3, 4} and Solachuddin Jauhari Arief Ichwan⁵

¹Department of Nutrition Sciences, Kulliyyah of Allied Health Sciences, International Islamic University Malaysia (IIUM), Jalan Sultan Ahmed Shah, Bandar Indera Mahkota Kuantan, 25200 Pahang Darul Makmur, MALAYSIA

²Non Communicable Diseases Research Unit, Kulliyyah of Medicine, International Islamic University Malaysia (IIUM), Jalan Sultan Ahmad Shah, Bandar Indera Mahkota, 25200 Kuantan, Pahang Darul Makmur, MALAYSIA;International Institute for Halal Research and Training (INHART), E5 2-2, Level 2, Block E5, Kulliyyah of Engineering, International Islamic University Malaysia (IIUM), P.O. Box 10 Kuala Lumpur, MALAYSIA

³Non Communicable Diseases Research Unit, Kulliyyah of Medicine, International Islamic University Malaysia (IIUM), Jalan Sultan Ahmad Shah, Bandar Indera Mahkota, 25200 Kuantan, Pahang Darul Makmur, MALAYSIA

⁴International Institute for Halal Research and Training (INHART), E5 2-2, Level 2, Block E5, Kulliyyah of Engineering, International Islamic University Malaysia (IIUM), P.O. Box 10 Kuala Lumpur, MALAYSIA;Department of Pharmaceutical Technology, Kulliyyah of Pharmacy, International Islamic University Malaysia (IIUM), Jalan Sultan Ahmad Shah, Bandar Indera Mahkota, 25200 Kuantan, Pahang Darul Makmur, MALAYSIA

⁵Department of Basic Medical Sciences, Kulliyyah of Dentistry, International Islamic University Malaysia (IIUM), Jalan Sultan Ahmad Shah, Bandar Indera Mahkota, 25200 Kuantan, Pahang Darul Makmur, MALAYSIA

Cite this paper:
Nuraniza Azahari, Muhammad Muzaffar Ali Khan Khattak, Muhammad Taher and Solachuddin Jauhari Arief Ichwan. Dose Water Extract of Cinnamon (Cinnamomum Zeylanicum) Exhibits Anti-Diabetic Properties in Cultured 3T3-L1 Adipocytes: A Concurrent Assessment of Adipogenesis, Lipolysis and Glucose Uptakes. Journal of Food and Nutrition Research. 2014; 2(11):764-769. doi: 10.12691/jfnr-2-11-1

Abstract

Cinnamon is a common spice which is widely advocated for its efficacy controlling of hyperglycemia. However, the mechanism of action has yet to be established for the effect on the blood glucose concentration. Cinnamon was extracted with water and induced to cell line namely 3T3-L1 preadipocyte (American Type cell Culture Collection). The cell proliferation, differentiation (adipogenesis) and glucose uptake activity were assessed by measuring the uptake of radio-labelled glucose. Furthermore, for comparison glucose oxidase assay was also performed by using Glucose Assay Kit (Sigma-Aldrich, Inc). The collected data was statistically analysed using SPSS version 12.0 for any possible differences. This study revealed that there was a significant (P<0.01) increase the activity/adipogenesis. This increase activity was accompanied by significant (P<0.01) increase in the glucose uptake and reduced catalytic activity of lipids (lipolysis). The finding reveals that C. Zeylanicum extract has similar effect to that of insulin activity. The present study suggests that the cinnamon enhances glucose uptakes, reduces the lipid breakdown and resembles insulin activity.

Keywords:
cinnamon 3T3-L1 adipocytes adipogenesis glucose uptake glucose oxidase

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