Effect of Hibiscus sabdariffa Tea Extracts Intake on the Atherosclerosis Biomarkers in Adults

Asmaa Talal Al-Malki^1, , Heba Abbas Ahmed Sindi² and Mohammed Hussain Al-Qahtani³

¹Department of Food and Nutrition Science, Faculty of Science, Taif University, Taif, Saudi Arabia

²Department of Food and Nutrition, Faculty of Human Sciences and Designs, King Abdul-Aziz University, Jeddah, Saudi Arabia

³Centre of Excellence in Genomic Medicine Research (Cegmr) King Abdulaziz University (Kau), Jeddah, Saudi Arabia

Cite this paper:
Asmaa Talal Al-Malki, Heba Abbas Ahmed Sindi and Mohammed Hussain Al-Qahtani. Effect of Hibiscus sabdariffa Tea Extracts Intake on the Atherosclerosis Biomarkers in Adults. Journal of Food and Nutrition Research. 2021; 9(1):40-44. doi: 10.12691/jfnr-9-1-6

Abstract

Purpose: In Saudi Arabia, about 46% of total of deaths caused by Cardiovascular diseases (CVDs). Recently, an association between the bioactive components in Hibiscus sabdariffa and atherosclerosis prevention was detected. The present study aimed to examine the influence of anthocyanins from Hibiscus sabdariffa tea extracts on the atherosclerosis biomarkers in adults in Saudi Arabia. Patients and Methods: 16 female Participants, with mean age was of about 20-35 years were asked to fast for 12 hours after 3 days washout, then blood sample were collected and blood pressure were measured before and after consumption of Hibiscus sabdariffa tea extract. All, participants consumed. H. sabdariffa tea extract (240 ml tea bag) twice a day for 6 weeks. blood sample and blood pressure were collected at the end of intervention. Biochemical analysis, determination of Antioxidant concentration and determination of oxidized low-density lipoprotein (OxLDL) Levels were carried out. Results: A significant decline in blood pressure (systolic and diastolic) and OxLDL for the participants while no changes in levels of LDL, TG, cholesterol and the rate of glucose. A significant increase in HDL was, also, observed. The study found that there were no significant differences in participants antioxidants concentration. Conclusion: The study suggests that anthocyanins from H. Sabdariffa may have an effective role in preventing of atherosclerosis due to the influence of relevant biomarkers related.

Keywords:
anthocyanins cardiovascular diseases bioactive components antioxidants

This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References:

[1]	Alwan, A., Armstrong, T., Bettcher, D., Boerma, T., Branca, F., Ho, J. C.Y., Mathers, C., Martinez, R., Poznyak, V., Roglic, G., Riley, L., d`Espaignet, E., Stevens, G., Taubert, K. and Xuereb, G. Global atlas on cardiovascular disease prevention and control, by the World Health Organization in collaboration with the World Heart Federation and the World Stroke Organization, 2011.
[2]	Riley, L. and Cowan, M. Noncommunicable diseases (NCD). Country Profiles. Switzerland: World Health Organization, 2014. https://www.who.int/nmh/publications/ncd-profiles-2014/en/.
[3]	Wallace, T.C. Anthocyanin in cardiovascular disease. Advances in Nutrition, 2(1):1-7.2011.
[4]	Khoo, H.E., Azlan, A., Ismail, A., Abas, F. and Hamid, M. Inhibition of Oxidative Stress and Lipid Peroxidation by Anthocyanins from Defatted. Canarium odontophyllum. Pericarp and Peel Using In Vitro Bioassays. PLoS ONE, 9; 9(1): e81447. 2014.
[5]	Hopkins, A.L., Lamm, M.G., Funk, J.L. and Ritenbaugh, C.h. Hibiscus sabdariffa L. in the treatment of hypertension and hyperlipidaemia: a comprehensive review of animal and human studies. Fitoterapia. 85: 84-94.2013.
[6]	Mozaffari-Khosravi, H., Jalali-Khanabadi, B.A., Afkhami-Ardekani, M. and Fatehi, F. Effects of sour tea (Hibiscus sabdariffa) on lipid profile and lipoproteins in patients with type II diabetes. J Altern Complement Med, 15(8): 899-903. 2009.
[7]	Jin, Y., Alimbetov, D., George, T., Gordon, M.H. and Lovegrove, J.A. A randomised trial to investigate the effects of acute consumption of a blackcurrant juice drink on markers of vascular reactivity and bioavailability of anthocyanins in human subjects. Eur J Clin Nutr, 65(7): 849-56.2011.
[8]	McKay, D.L., Chen, C.Y., Saltzman, E. and Blumberg, J.B. Hibiscus Sabdariffa L. Tea (tisane) lowers blood pressure in prehypertensive and mildly hypertensive adults. J Nutr, 140(2): 298-303.2010.
[9]	Mazza, G.J. Anthocyanins and heart health. Ann Ist Super Sanita, 43(4): 369-74. 2007.
[10]	Hollander, W. Role of hypertension in atherosclerosis and cardiovascular disease. Am J Cardiol, 38(6): 786-800. 1976.
[11]	Hadi, H.A.R., Carr, C.S. and Al Suwaidi, J. Endothelial dysfunction: cardiovascular risk factors, therapy and outcome. Vasc Health Risk Manag, 1(3): 183-98. 2005.
[12]	Yi, L., Chen, Ch-y., Jin, X., Mi, M-t., Yu, B., Chang, H., Ling, W-h. and Zhang, T. Structural requirements of anthocyanins in relation to inhibition of endothelial injury induced by oxidized low-density lipoprotein and correlation with radical scavenging activity. FEBS Lett, 3(5): 583-590. 2010.
[13]	Chang, Y.C., Huang, K.X., Huang, A.C., Ho, Y.C. and Wang, C.J. Hibiscus anthocyanins-rich extract inhibited LDL oxidation and OxLDL-mediated macrophages apoptosis. Food Chem Toxicol, 44(7): 1015-23. 2006.
[14]	Aziz, Z., Wong, S.Y. and Chong, N.J. Effects of Hibiscus sabdariffa L. on serum lipids: a systematic review and meta-analysis. J Ethnopharmacol, 150(2): 442-50. 2013.
[15]	Lefevre, M., Wiles, J.E., Zhang, X., Howard, L.R., Gupta, S., Smith, A.A., Ju, Z.Y. and DeLany, J.P. Gene expression microarray analysis of the effects of grape anthocyanins in mice: a test of a hypothesis-generating paradigm. Metabolism, 57(suppl 1): S52-S57. 2008.
[16]	Da-Costa-Rocha, I., BonnLaender, B., Sievers, H., Pischel, I. and Heinrich, M. Hibiscus sabdariffa L. A phytochemical and pharmacological review. Food Chem, 15; 165: 424-443. 2014.
[17]	Mauray, A., Felgines, C., Morand, C., Mazur, A., Scalbert, A. and Milenkovic, D. Nutrigenomic analysis of the protective effects of bilberry anthocyanin-rich extract in apo E-deficient mice. Genes Nutr, 5(4): 343-353. 2010.
[18]	Mauray, A., Felgines, C., Morand, C., Mazur, A., Scalbert, A. and Milenkovic, D. Bilberry anthocyanin-rich extract alters expression of genes related to atherosclerosis development in aorta of apo E-deficient mice. Nutr Metab Cardiovasc Dis, 22(1): 72-80. 2012.