Slow Release Characteristics of β-Glucan

Liqing Lai¹, Vanja Perčulija¹, Jia Wu² and Lan Zhao^1,

¹College ofLife Sciences, Fujian Normal University, Fuzhou, 350117, China

²College of Biological Science and Engineering, Fuzhou University, Fuzhou, Fujian 350116, China

Cite this paper:
Liqing Lai, Vanja Perčulija, Jia Wu and Lan Zhao. Slow Release Characteristics of β-Glucan. Journal of Food and Nutrition Research. 2020; 8(2):102-109. doi: 10.12691/jfnr-8-2-5

Abstract

β-glucan freeze-thaw gel was used as a carrier to release curcumin. The results showed that the freeze-dried gel had the ideal sustained release following 5% β-glucan solution by adding 1% β-glucan quality curcumin, repeated freezing and thawing 8 times. The Peppas equation can significantly describe the release mechanism of curcumin in the β-glucan gel. This study further demonstrated that the release of curcumin in the oat β-glucan gel is the Fick diffusion mechanism and coated barley β-glucan is a non-Fick spread.

Keywords:
β-glucan cryogelation curcumin sustained-release non-Fick

This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References:

[1]	Chen F, Liu J, Ye F, et al. Synthesis and characterization of fatty Acid oat β-Glucan ester and its structure–curcumin loading capacity relationship[J]. Journal of Agricultural and Food Chemistry, 2014, 62(50): 56-64.
[2]	Jianhua Ming, Jinyun Ye, Yixiang Zhang, Qiyou Xu, Xia Yang, Xianping Shao, Jun Qiang, Pao Xu. Optimal dietary curcumin improved growth performance, and modulated innate immunity, antioxidant capacity and related genes expression of NF-κB and Nrf2 signaling pathways in grass carp ( Ctenopharyngodon idella ) after infection with aeromonas hydrophila[J]. Fish and Shellfish Immunology, 2020, 97.
[3]	Rohman A, Sudjadi, Devi, et al. Analysis of curcumin in curcuma longa and curcuma xanthorriza using FTIR spectroscopy and chemometrics[J]. Research Journal of Medicinal Plant, 2015(3): 155-160.
[4]	Hrmova M, Varghese J N, Høj P B, et al. Crystallization and preliminary x-ray analysis ofbeta-glucan exohydrolase isoenzyme exoI from barley (Hordeum vulgare)[J]. Acta Crystallographica, 1998, 54(Pt 4): 687-689.
[5]	Anitha A, Maya S, Deepa N, et al. Efficient water soluble o-carboxymethyl chitosannanocarrier for the delivery of curcumin to cancer cells[J]. Carbohydrate Polymers, 2011, 83(2): 452-461.
[6]	Tije A J, Verweij J, Loos W J, et al. Pharmacological effects of formulation vehicles: implications for cancer chemotherapy[J]. Clinical Pharmacokinetics, 2003, 42(7): 665-685.
[7]	Murillo Ortiz Blanca Olivia, Fuentes Preciado Alma Rosa, Ramírez Emiliano Joel, Martínez Garza Sandra, Ramos Rodríguez Edna, Alba Macías Luz Angélica. Recovery ofBone And Muscle Mass In Patients With Chronic Kidney Disease And Iron Overload On Hemodialysis And Taking Combined Supplementation With Curcumin And Resveratrol[J]. Clinical interventions in aging, 2019, 14.
[8]	Shen Liang, Ji Hong-Fang. Low stability remedies the low bioavailability of curcumin[J]. Trends in Molecular Medicine, 2012, 18(7).
[9]	Pettolino F A, Walsh C, Fincher G B, et al. Determining the polysaccharide composition of plant cell walls [J]. Nature Protocols, 2012, 7(9): 1590-1607.
[10]	Rui-ling Shen, Xiao-yun Liu, Ji-lin Dong, Jun-ling Si, Hong Li. The gel properties and microstructure of the mixture of oat β-glucan/soy protein isolates[J]. Food Hydrocolloids, 2015, 47.
[11]	Mazumder A, Neamati N, Sunder S, Schulz J, Pertz H, Eich E, Pommier Y. Curcumin analogs with altered potencies against HIV-1 integrase as probes for biochemical mechanisms of drug action[J]. Journal of Medicinal Chemistry, 1997, 40(19).
[12]	Liver Diseases and Conditions-Non-Alcoholic Fatty Liver Disease: Researchers from China Pharmaceutical University Describe Findings in Non-Alcoholic Fatty Liver Disease (Curcumin regulates endogenous and exogenous metabolism via Nrf2-FXR-LXR pathway in NAFLD mice)[J]. Biotech Week, 2018.
[13]	Sara Rasouli, Maryam Montazeri, Samira Mashayekhi, Shima Sadeghi-Soureh, Mehdi Dadashpour, Hanieh Mousazadeh, Abbas Nobakht, Nosratollah Zarghami, Younes Pilehvar-Soltanahmadi. Synergistic anticancer effects of electrospun nanofiber-mediated codelivery of curcumin and chrysin: Possible application in prevention of breast cancer local recurrence[J]. Journal ofDrug Delivery Science and Technology, 2019.
[14]	Yan Chen, Chen Chen, Xiaojuan Zhang, Chuanchuan He, Pengxuan Zhao, Minsi Li, Ting Fan, Ruicong Yan, Yao Lu, Robert J. Lee, Muhammad Waseem Khan, Muhammad Sarfraz, Xiang Ma, Tan Yang, Guangya Xiang. Platinum complexes of curcumin delivered by dual-responsive polymeric nanoparticles improve chemotherapeutic efficacy based on the enhanced anti-metastasis activity and reduce side effects[J].Acta Pharmaceutica Sinica B, 2019.
[15]	Karthika Chenmala, Sureshkumar Raman.Can curcumin along with chemotherapeutic drug and lipid provide an effective treatment of metastatic colon cancer and alter multidrug resistance[J]. Medical hypotheses, 2019, 132.
[16]	Obeid Mohammad A, Khadra Ibrahim, Albaloushi Abdullah, Mullin Margaret, Alyamani Hanin, Ferro Valerie A. Microfluidic manufacturing of different niosomes nanoparticles for curcumin encapsulation: Physical characteristics, encapsulation efficacy, and drug release[J]. Beilstein journal of nanotechnology, 2019, 10.
[17]	Lu Chao, Jiang Ling, Xu Weijie, Yu Feiyuan, Xia Wenquan, Pan Miao, Zhou Wen, Pan Xin, Wu Chuanbin, Liu Daojun. Poly (ethylene glycol) crosslinked multi-armed poly (ε-benzyloxycarbonyl -L-lysine)s as super-amphiphiles: Synthesis, self-assembly, and evaluation as efficient delivery systems for poorly water-soluble drugs[J]. Colloids and surfaces. B, Biointerfaces, 2019, 182.
[18]	Eleftherios Halevas, Barbara Mavroidi, Claudia H. Swanson, Graham C. Smith, Alexandra Moschona, Spyros Hadjispyrou, Athanasios Salifoglou, Anastasia A. Pantazaki, Maria Pelecanou, George Litsardakis. Magnetic cationic liposomal nanocarriers for the efficient drug delivery of a curcumin-based vanadium complex with anticancer potential[J]. Journal of Inorganic Biochemistry, 2019, 199.
[19]	Tije A J, Verweij J, Loos W J, et al. Pharmacological effects of formulation vehicles: implications for cancer chemotherapy[J]. Clinical Pharmacokinetics, 2003, 42(7): 665-685.
[20]	Alzagameem Abla, Klein Stephanie Elisabeth, Bergs Michel, Do Xuan Tung, Korte Imke, Dohlen Sophia, Hüwe Carina, Kreyenschmidt Judith, Kamm Birgit, Larkins Michael, Schulze Margit. Antimicrobial Activity of Lignin and Lignin-Derived Cellulose and Chitosan Composites Against Selected Pathogenic and Spoilage Microorganisms[J]. Polymers, 2019, 11(4).
[21]	Shipley Bill, Douma Jacob C. Generalized AIC and chi-squared statistics for path models consistent with directed acyclic graphs[J]. Ecology, 2019.
[22]	Skoug J W, Mikelsons M V, Vigneron C N, et al. qualitative evaluation of the mechanism ofrelease of matrix sustained release dosage forms by measurement of polymer release[J]. Journal of Controlled Release, 1993, 27(3): 227-245.