Journal of Cancer Research and Treatment
ISSN (Print): 2374-1996 ISSN (Online): 2374-2003 Website: http://www.sciepub.com/journal/jcrt Editor-in-chief: Jean Rommelaere
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Journal of Cancer Research and Treatment. 2013, 1(2), 36-38
DOI: 10.12691/jcrt-1-2-3
Open AccessEditorial

Statins: A New Hope for Cancer Therapy

Ahmed Mohammed Kabel1,

1Department of Pharmacology, Faculty of Medicine, Tanta University, Tanta, Egypt

Pub. Date: September 26, 2013

Cite this paper:
Ahmed Mohammed Kabel. Statins: A New Hope for Cancer Therapy. Journal of Cancer Research and Treatment. 2013; 1(2):36-38. doi: 10.12691/jcrt-1-2-3

Abstract

3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase is the key enzyme in cholesterol synthesis. Statins are used in treatment of hypercholesterolemia as inhibitors of HMG-CoA reductase. Cancer cells overexpress HMG-CoA reductase enzyme. Recent studies have demonstrated that statins may inhibit the proliferation of human breast cancer cells. Statins have proangiogenic effects in low therapeutic concentrations and angiostatic effects in higher concentrations. Statins induce apoptosis and reduce cell invasiveness in various cell lines, including malignant glioma, neuroblastoma and myeloid leukemia. The chemopreventive activity of statins against cancer is suggested to depend on inhibition of cholesterol synthesis together with their antioxidant and anti-inflammatory properties.

Keywords:
cholesterol statins cancer HMG-CoA

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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