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Taylor F, Ward K, Moore TH et al. Statins for the primary prevention of cardiovascular disease". In Taylor, Fiona. Cochrane Database Syst Rev 2011; 1: CD004816.

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Article

Statins: A New Hope for Cancer Therapy

1Department of Pharmacology, Faculty of Medicine, Tanta University, Tanta, Egypt


Journal of Cancer Research and Treatment. 2013, Vol. 1 No. 2, 36-38
DOI: 10.12691/jcrt-1-2-3
Copyright © 2013 Science and Education Publishing

Cite this paper:
Ahmed Mohammed Kabel. Statins: A New Hope for Cancer Therapy. Journal of Cancer Research and Treatment. 2013; 1(2):36-38. doi: 10.12691/jcrt-1-2-3.

Correspondence to: Ahmed Mohammed Kabel, Department of Pharmacology, Faculty of Medicine, Tanta University, Tanta, Egypt. Email: drakabel@gmail.com

Abstract

3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase is the key enzyme in cholesterol synthesis. Statins are used in treatment of hypercholesterolemia as inhibitors of HMG-CoA reductase. Cancer cells overexpress HMG-CoA reductase enzyme. Recent studies have demonstrated that statins may inhibit the proliferation of human breast cancer cells. Statins have proangiogenic effects in low therapeutic concentrations and angiostatic effects in higher concentrations. Statins induce apoptosis and reduce cell invasiveness in various cell lines, including malignant glioma, neuroblastoma and myeloid leukemia. The chemopreventive activity of statins against cancer is suggested to depend on inhibition of cholesterol synthesis together with their antioxidant and anti-inflammatory properties.

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