Synchronous Primary Malignancies of the Kidney and Colon: A Rare Case

Mazaher Ramezani¹, Setareh Afzali² and Masoud Sadeghi^3,

¹Molecular Pathology Research Center, Emam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran

²Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran

³Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

Cite this paper:
Mazaher Ramezani, Setareh Afzali and Masoud Sadeghi. Synchronous Primary Malignancies of the Kidney and Colon: A Rare Case. American Journal of Cancer Prevention. 2016; 4(4):51-53. doi: 10.12691/ajcp-4-4-1

Abstract

The coexistent diagnosis of colorectal cancer and renal cell carcinoma is rare. We reported a 55-year-old woman with history of recurrent UTI, who was admitted to Urology Clinic with left flank pain for the evaluation of renal stone. Ultrasound examination revealed a homogenous mass measuring 4.7cm with a calcified focus in left kidney. Macroscopic evaluation revealed a renal mass in lower pole, 5cm in maximum diameter with variegated cut surface. The pathology report showed clear cell carcinoma of kidney. The patient had a colonoscopy report of many polyps in the entire length of colon with a clinical impression of familial adenomatous polyposis since last year but with no genetic confirmatory tests Since last year, the pathology report showed well differentiated adenocarcinoma of colon invading to submucosa with no vascular and perineural invasion in the distal margin of colon. In family history, her passed brother had colon cancer and her sister was alive with colon cancer that had a colostomy. In summary, the existence of both kidney and colon cancers occurs more in elderly patients. Also, the existence of colon adenocarcinoma with numerous polyps can be a risk factor for the second malignancy that the physicians must pay attention to this point in their follow-up.

Keywords:
colorectal cancer renal cell carcinoma polyp

This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References:

[1]	Cullinane CA, Jarrahy R, Wilson TG, Ellenhorn JD. Asymptomatic renal neoplasms in the rectal cancer patient. Am Surg. 2001; 67(12):1162-4.
[2]	Bhargava A, O'Callaghan M, Abdelhafiz T, Downey P, Nasr A, Nibhraonain S, et al. Synchronous sigmoid and caecal cancers together with a primary renal cell carcinoma. Ir J Med Sci. 2012; 181(2):273-6.
[3]	Amoroso A, Del Porto F, Garzia P, Ilardi M, Clemenzia C, D'Amato A, et al. The infrequent association of synchronous renal and colonic malignancies. Eur Rev Med Pharmacol Sci. 1999; 3(3): 111-4.
[4]	Steinhagen E , Moore HG, Lee-Kong SA, Shia J, Eaton A, Markowitz AJ, et al. Patients with colorectal and renal cell carcinoma diagnoses appear to be at risk for additional malignancies. Clin Colorectal Cancer. 2013;12(1):23-7.
[5]	Calderwood AH, Huo D, Rubin DT. Association between colorectal cancer and urologic cancers. Arch Intern Med 2008;168:1003-9.
[6]	Fazzin M, Dellachiesa L, Resta G, Bandi M, Marino S, Anania G. One-stage laparoscopic procedure for a patient with bilateral colorectal tumours and renal carcinoma. G Chir. 2013;34(4):132-4.
[7]	Czene K, Hemminki K. Kidney cancer in the Swedish Family Cancer Database: familial risks and second primary malignancies. Kidney Int.2002;61(5):1806-13.
[8]	Mydlo JH, Gerstein M. Patients with urologic cancer and other nonurologic malignancies: analysis of a sample and review of the literature. Urology. 2001;58(6):864-9.
[9]	D'Amato A, Gentili V, Santella S, Pronio A, Montesani C. [Synchronous neoplasms of the colon and kidney: analysis of 2 case reports]. Chir Ital. 2000;52(1):83-6.
[10]	Papalampros AE, Petrou AS, Mantonakis EI, Evangelou KI, Giannopoulos LA, Marinos GG, et al. Coexistence of a colon carcinoma with two distinct renal cell carcinomas: a case report. J Med Case Rep. 2011;5:134.
[11]	Kozokic A, Surlin V, Petrovic B, Petrovic V, Prvanovic G, Beraru I, et al. Considerations upon a case of synchronous primary malignancies: adenocarcinoma of the sigmoid and clear cell carcinoma of the right kidney. Rom J Morphol Embryol. 2011; 52(1 Suppl): 509-11.
[12]	Ahmadnia H, Molaei M. Concomitant presence of renal cell carcinoma and adenocarcinoma of the colon. Saudi J Kidney Dis Transpl. 2009;20(6):1081-2.
[13]	Turati L, Steccanella F , Petrelli F , Vitali E , Barni S , Sgroi G . Signet-ring cell carcinoma of the rectum and synchronous renal cell carcinoma in a young man. Int J Colorectal Dis. 2016; 31(5): 1071-2.
[14]	Spajić B, Grubisić I, Spajić M, Marusić Z, Demirović A, Mijić A, et al. Synchronous rectal adenocarcinoma and bilateral clear cell renal carcinoma. Acta Clin Croat. 2010;49(2):169-72.
[15]	Martin Arnau AB, Ochoa Vargas C, Peña Gonzalez JA, Targarona Soler EM. Simultaneous colectomy and nephectomy in synchronic tumours. Cir Esp. 2015;93(4):266-8.
[16]	Dafashy TJ, Ghaffary CK, Keyes KT, Sonstein J. Synchronous Renal Cell Carcinoma and Gastrointestinal Malignancies. Case Rep Urol. 2016;2016:7329463.