Journal of Food and Nutrition Research
ISSN (Print): 2333-1119 ISSN (Online): 2333-1240 Website: Editor-in-chief: Prabhat Kumar Mandal
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Journal of Food and Nutrition Research. 2018, 6(9), 584-589
DOI: 10.12691/jfnr-6-9-7
Open AccessArticle

Macronutrient Preload effect on Glycaemic Control and Pregnancy Outcome in Gestational Diabetes Mellitus

Cai Jingjing1, Lv Jing1, Guo Qianying1, Wang Boshi1, Gunnar Norstedt2, Magnus Sederholm2 and Liu Peng1,

1Department of Clinical Nutrition, Peking University People’s Hospital, Beijing, China

2Department of Women’s and Children’s Health, Karolinska Institute, Stockholm, Sweden

Pub. Date: September 26, 2018

Cite this paper:
Cai Jingjing, Lv Jing, Guo Qianying, Wang Boshi, Gunnar Norstedt, Magnus Sederholm and Liu Peng. Macronutrient Preload effect on Glycaemic Control and Pregnancy Outcome in Gestational Diabetes Mellitus. Journal of Food and Nutrition Research. 2018; 6(9):584-589. doi: 10.12691/jfnr-6-9-7


Objective: To investigate the effect of macronutrient preload treatment, MPT, on glycemic control and pregnancy outcome in gestational diabetes mellitus, GDM. Study Design: 40 patients with GDM were randomized to either MPT in addition to health education and dietary guidance (n=25) or health education and dietary guidance only (n=15). MPT was given three times/day, 30 minutes before regular meals and continued until term. Participants were subjected physical examination, laboratory analysis and pregnancy outcomes. Results: The time until the participant reached stable euglycemia was shorter in the preload group compared to controls (P<0.05), in patients ≥30 years old (1.3±0.55 versus 2.5±1.1 weeks, P<0.05), in pre-gestational BMI<24 kg/m2 (1.3±0.58 versus 1.9±0.69 weeks, P<0.05) and in pre-gestational BMI≥24 kg/m2 (1.2±0.44 versus 2.6±1.32 weeks, P<0.05). The birth weight in the subgroup of BMI>24 kg/m2 was lower in the MTP group compared to the control group (3124±523g versus 3780.0±472g, P<0.05). Increase of HbA1c ≥5% was significantly lower after preload treatment. Conclusion; MPT can safely be used in patients with gestational diabetes mellitus for effective control of blood glucose. The significant reduction of birth weight in participants with pre-gestational BMI ≥24kg/m2 indicates that preload can be used to control negative effects of hyperglycemia, with reduced risk for complications during delivery.

gestational diabetes mellitus macronutrient preload treatment glycemic control pre-gestational BMI nutritional therapy

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