Protective Effect of Wheat Derived Non-specific lipid-transfer Protein 2 on Vascular Endothelium Inflammation

Emanuela Leoncini¹, Cecilia Prata², Marco Malaguti¹, Cristina Angeloni³, Luca Massaccesi¹, Sara Bosi⁴, Valeria Bregola⁴, Ilaria Marotti⁴, Giovanni Dinelli⁴ and Silvana Hrelia^1,

¹Department for Life Quality Studies, Alma Mater Studiorum, University of Bologna, 47921 Rimini, Italy

²Department of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy

³School of Pharmacy, University of Camerino, Camerino, Italy

⁴Department of Agricultural and Food Sciences, Alma Mater Studiorum, University of Bologna, 40127 Bologna, Italy

Cite this paper:
Emanuela Leoncini, Cecilia Prata, Marco Malaguti, Cristina Angeloni, Luca Massaccesi, Sara Bosi, Valeria Bregola, Ilaria Marotti, Giovanni Dinelli and Silvana Hrelia. Protective Effect of Wheat Derived Non-specific lipid-transfer Protein 2 on Vascular Endothelium Inflammation. Journal of Food and Nutrition Research. 2018; 6(6):386-392. doi: 10.12691/jfnr-6-6-6

Abstract

The important functions of the endothelium and the relationship between cardiovascular risk factors and endothelial dysfunction suggest the primary role of this tissue as a target for dietary strategies aimed at the prevention from related diseases. Cereals are key component of a healthy and balanced diet, and the presence of non-specific lipid-transfer protein 2 (nsLTP2) in wheat represents an added value to contribute to maintain the functionality of the vascular endothelium and consequently of the cardiovascular system. Indeed, nsLTP2 downregulates the expression of the main cell adhesion molecules induced by a pro-inflammatory cytokine and, meanwhile, upregulates heme oxigenase-1, exerting a cytoprotective/anti-inflammatory activity. Therefore, nsLTP2 might represent a food-derived tool to protect the vascular system against several pathological conditions.

Keywords:
wheat bioactive peptides nsLTP2 vascular endothelium cytoprotection inflammation

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