Food Supplement 20170307-EGR May Increase the Number of Mesenchymal Stem Cells and the Effect of Mitochondrial Protection

Ying-Chieh Lai¹, Hsien-Chang Li¹, Shun-Chieh Yang², Chi-Tang Tu², Han-Chung Cheng² and Shou-Jen Lan^2,

¹Department of Healthcare Administration, Asia University, Taiwan

²R&D Project Manager, Taiwan Mitochondrion Applied Technology Co.,Ltd

Cite this paper:
Ying-Chieh Lai, Hsien-Chang Li, Shun-Chieh Yang, Chi-Tang Tu, Han-Chung Cheng and Shou-Jen Lan. Food Supplement 20170307-EGR May Increase the Number of Mesenchymal Stem Cells and the Effect of Mitochondrial Protection. Journal of Food and Nutrition Research. 2017; 5(8):569-574. doi: 10.12691/jfnr-5-8-6

Abstract

A few refer to food supplements that can increase the number of mesenchymal stem cells and protect the mitochondria. We measured the amount of mesenchymal stem cells and the activity of the mitochondria in the plant extracts of the culture medium to evaluate the antiaging effect of the food extract of the plant extract. The samples were evaluated for human fat in mesenchymal stem cells, centrifuged to isolate the number of granulocytes, mesenchymal stem cells and increase mitochondrial ATP, and reduce free radical leakage, all associated with aging markers. Our results show that the number of mesenchymal stem cells increased by 39%, the energy of the mitochondrial ATP increased significantly and decreased free radical leakage. This suggests that our plant extracts in food supplements may help revive with antiaging.

Keywords:
food supplement stem cell mitochondria ATP

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References:

[1]	Alexander W. Mühleipa FJ, Christoph Wiggeb,c,1, Achilleas S. Frangakisb,c, Werner Kühlbrandta,2,, and Karen M. Daviesa, 3,4. 2015. Helical arrays of U-shaped ATP synthase dimers form.pdf. PMS
[2]	Bognar E, Sarszegi Z, Szabo A, Debreceni B, Kalman N, et al. 2013. Antioxidant and anti-inflammatory effects in RAW264.7 macrophages of malvidin, a major red wine polyphenol. PloS one 8:e65355
[3]	Burgess RJ, Agathocleous M, Morrison SJ. 2014. Metabolic regulation of stem cell function. Journal of internal medicine 276:12-24.
[4]	Chu X, Guo Y, Xu B, Li W, Lin Y, et al. 2015. Effects of Tannic Acid, Green Tea and Red Wine on hERG Channels Expressed in HEK293 Cells. PloS one 10:e0143797.
[5]	Chularojmontri L, Suwatronnakorn M, Wattanapitayakul SK. 2013. Phyllanthus emblica L. Enhances Human Umbilical Vein Endothelial Wound Healing and Sprouting. Evidence-based complementary and alternative medicine : eCAM 2013:720728.
[6]	Golechha M, Sarangal V, Ojha S, Bhatia J, Arya DS. 2014. Anti-Inflammatory Effect of Emblica officinalis in Rodent Models of Acute and Chronic Inflammation: Involvement of Possible Mechanisms. International journal of inflammation 2014:178408.
[7]	Hazra B, Sarkar R, Biswas S, Mandal N. 2010. Comparative study of the antioxidant and reactive oxygen species scavenging properties in the extracts of the fruits of Terminalia chebula, Terminalia belerica and Emblica officinalis. BMC complementary and alternative medicine 10:20.
[8]	Jung Y, Brack AS. 2014. Cellular mechanisms of somatic stem cell aging. Current topics in developmental biology 107:405-38.
[9]	MacLean AL, Kirk PD, Stumpf MP. 2015. Cellular population dynamics control the robustness of the stem cell niche. Biology open 4:1420-6.
[10]	McCully JD, Levitsky S, Del Nido PJ, Cowan DB. 2016. Mitochondrial transplantation for therapeutic use. Clinical and translational medicine 5:16.
[11]	Peng X, Zhou R, Wang B, Yu X, Yang X, et al. 2014. Effect of green tea consumption on blood pressure: a meta-analysis of 13 randomized controlled trials. Scientific reports 4:6251.
[12]	Richard B. Richardson1, Harper3 aM-E. 2016. Mitochondrial stress controls the radiosensitivity of the oxygen.pdf. Oncotarget.
[13]	Royce SG, Dang W, Yuan G, Tran J, El Osta A, et al. 2011. Resveratrol has protective effects against airway remodeling and airway hyperreactivity in a murine model of allergic airways disease. Pathobiology of aging & age related diseases 1.
[14]	Samidha A Kalekar1 RPMaUMT. 2013. Do plants mediate their anti-diabetic effects.pdf. Kalekar et al. BMC Complementary and Alternative Medicine
[15]	Xinxian Zhu JW, Yang Ou, Weiwei Han and Huaifang Li*. 2013. Polyphenol extract of Phyllanthus emblica (PEEP)induces inhibition of cell proliferation and triggers apoptosis in cervical cancer cells. EUROPEAN JOURNAL OF MEDICAL RESEARCH.
[16]	Ye T, Zhen J, Du Y, Zhou JK, Peng A, et al. 2015. Green tea polyphenol (-)-epigallocatechin-3-gallate restores Nrf2 activity and ameliorates crescentic glomerulonephritis. PloS one 10:e0119543.
[17]	Zhang L, Marsboom G, Glick D, Zhang Y, Toth PT, et al. 2014. Bioenergetic shifts during transitions between stem cell states (2013 Grover Conference series). Pulmonary circulation 4:387-94.