Journal of Food and Nutrition Research
ISSN (Print): 2333-1119 ISSN (Online): 2333-1240 Website: https://www.sciepub.com/journal/jfnr Editor-in-chief: Prabhat Kumar Mandal
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Journal of Food and Nutrition Research. 2017, 5(5), 285-292
DOI: 10.12691/jfnr-5-5-1
Open AccessArticle

The Divergent Effect of Coffee Polyphenol and Hydroxyhydroquinone Ingestion on Postprandial Hyperglycemia and Vascular Function in Healthy Men

Hiroko Jokura1, Isamu Watanabe1, Yoshie Fujii1, Mika Umeda1, Koichi Misawa1 and Akira Shimotoyodome2,

1Biological Science Laboratories, Kao Corporation, 2606 Akabane, Ichikai-machi, Haga-gun, Tochigi 321-3497, Japan

2Health Care Food Research Laboratories, Kao Corporation, Address: 2-1-3 Bunka, Sumida-ku, Tokyo 131-8501, Japan

Pub. Date: April 14, 2017

Cite this paper:
Hiroko Jokura, Isamu Watanabe, Yoshie Fujii, Mika Umeda, Koichi Misawa and Akira Shimotoyodome. The Divergent Effect of Coffee Polyphenol and Hydroxyhydroquinone Ingestion on Postprandial Hyperglycemia and Vascular Function in Healthy Men. Journal of Food and Nutrition Research. 2017; 5(5):285-292. doi: 10.12691/jfnr-5-5-1

Abstract

Epidemiological studies indicate that coffee consumption reduces the risk of diabetes and cardiovascular diseases. However, interventional studies have failed to clarify the beneficial effects of coffee consumption on blood glucose and the cardiovascular system. We previously demonstrated that 1) coffee polyphenol (CPP) consumption improved postprandial hyperglycemia and vascular endothelial function in humans, and 2) improvement in vascular endothelial function due to CPP was impaired by hydroxyhydroquinone (HHQ) in rats. This study aimed to elucidate the impact of concomitant consumption of HHQ, a prooxidant in coffee, on the beneficial effects of CPP consumption on postprandial blood glucose and vascular function in humans. We conducted a single-blind, randomized, placebo-controlled, crossover intervention study in healthy male adults, measuring blood and urine parameters and flow-mediated dilation after ingestion of a meal with CPP with or without HHQ up to 180 min postprandially. Ten healthy male adults consumed a test meal with either a placebo, control (CPP with HHQ), or active (CPP without HHQ) beverage. The CPP-including active (without HHQ) beverage significantly blunted the postprandial increase in blood glucose and decline in flow-mediated dilation but not the control (with HHQ) beverage, compared with the placebo beverage. The active beverage reduced blood oxidative stress biomarker response compared with the control beverage. In conclusion, these results demonstrate that concomitant ingestion of HHQ, which increases oxidative stress, interferes with the improvement of postprandial blood glucose and vascular endothelial function after CPP consumption in healthy humans.

Keywords:
adult men coffee polyphenol flow-mediated dilatation hydroxyhydroquinone oxidative stress postprandial blood glucose

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References:

[1]  Takami, H., Nakamoto, M., Uemura, H., Katsuura, S., Yamaguchi, M., Hiyoshi, M., Sawachika, F., Juta, T., Arisawa, K, “Inverse correlation between coffee consumption and prevalence of metabolic syndrome baseline survey of the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study in Tokushima, Japan”, Journal of Epidemiology, 23, pp. 12-20, 2013.
 
[2]  Grosso, G., Marventano, S., Galvano, F., Pajak, A., Mistretta, A, “Factors associated with metabolic syndrome in a Mediterranean population: role of caffeinated beverages”, Journal of Epidemiology, 24, pp. 327-333, 2014.
 
[3]  Grosso, G., Stepaniak, U., Micek, A., Topor-Mądry, R., Pikhart, H., Szafraniec, K., Pajak, A. “Association of daily coffee and tea consumption and metabolic syndrome: results from the Polish arm of the HAPIEE study”, European Journal of Nutrition, 54, pp. 1129-1137, 2014.
 
[4]  Van Dam, RM., Hu, FB, “Coffee consumption and risk of type 2 diabetes”, Journal of American Medical Association, 294, pp. 97-104, 2005.
 
[5]  Sugiyama, K., Kuriyama, S., Akhter, M., Kakizaki, M., Nakaya, N., Ohmori-Matsuda, K., Shimazu, T., Nagai, M., Sugawara, Y., Hozawa, A., Fukao, A., Tsuiji, I, “Coffee consumption and mortality due to all causes, cardiovascular diseases, and cancer in Japanese women”, The Journal of Nutrition, 140, pp. 1007-1013, 2010.
 
[6]  Van Dam, RM., Willett, WC., Manson, JE., Hu FB, “Coffee caffeine and risk of type 2 diabetes: A prospective cohort study in younger and middle-aged U.S. women”, Diabetes Care, 29, pp. 398-403, 2006.
 
[7]  Godos, J., Pluchinotta, FR., Marventano, S., Buscemi, S., Li Volti, G., Galvano, F., Grosso, G., “Coffee components and cardiovascular risk: beneficial and detrimental effects” International Journal of Food Sciences and Nutrition, 65, pp. 925-936, 2014.
 
[8]  Fukushima, Y., Ohie, T., Yonekawa, Y., Ohie, T., Yonekawa, Y., Yonemoto, K., Aizawa, H., Mori, Y., Watanabe, M., Takeuchi, M., Kondo, K, “Coffee and green tea as a large source of antioxidant polyphenols in the Japanese population”, Journal of Agriculture and Food Chemistry, 57, pp. 1253-1259, 2009.
 
[9]  Fraga, CG., Galleano, M., Verstraeten, SV., Oteiza, PI, “Basic biochemical mechanisms behind the health benefits of polyphenols”, Molecular Aspects of Medicine, 31, pp. 435-445, 2010.
 
[10]  Clifford, MN, “Chlorogenic acids and other cinnamates-nature, occurrence and dietary burden”, Journal of Science of Food and Agriculture, 79, pp. 362-372, 1999.
 
[11]  Jokura, H., Watanabe, I., Umeda, M., Hase, T., Shimotoyodome, A, “Coffee polyphenol consumption improves postprandial hyperglycemia associated with impaired vascular endothelial function in healthy male adults”, Nutrition Research, 35, pp. 873-881, 2015.
 
[12]  Kubota, T., Kubota, N., Kumagai, H., Yamaguchi, S., Kozono, H., Takahashi, T., Inoue, M., Itoh, S., Takamoto, I., Sasako, T., Kumagai, T., Kawai, T., Hashimoto, S., Kobayashi, T., Sato, M., Tokuyama, K., Nashimura, S., Tsunoda, M., Ide, T., Murakami, K., Yamazaki, T., Ezaki, O., Kawamura, K., Masuda, H., Moroi, M., Sugi, K., Oike, Y., Shimokaa, H., Yanagihara, N., Tsutsui, M., Terauchi, Y., Tobe, K., Nagai, R., Kamata, K., Inoue, K., Komada, T., Ueki, K., Kadowaki, T, “Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle”, Cell Metabolism, 13, pp. 294-307, 2011.
 
[13]  Kawano, H., Motoyama, T., Hirashima, O., Hirai, N., Miyao, Y., Sakamoto, T., Kugiyama, K., Ogawa, H., Yasue, H, “Hyperglycemia rapidly suppresses flow-mediated endothelium-dependent vasodilation of brachial artery”, Journal of American College of Cardiology, 34, pp. 146-154, 1999.
 
[14]  Lawrence, M., Peter, M., Cummings, BA., Karen, G., Bassam, A., Nassar, MB, “Oral glucose loading acutely attenuates endothelium-dependent vasodilation in healthy adults without diabetes: an effect prevented by vitamins C and E”, Journal of American College of Cardiology, 36, pp. 2185-2191, 2000.
 
[15]  Halliwell, B., Long, LH., Yee, TP., Lim, S., Kelly, R, “Establishing biomarkers of oxidative stress: the measurement of hydrogen peroxide in human urine”, Current Medicinal Chemistry, 11, pp. 1085-1092, 2004.
 
[16]  Hiramoto, K., Mochizuki, R., Kikugawa, K, “Generation of hydrogen peroxide from hydroxyhydroquinone and its inhibition by superoxide dismutase”, Journal of Oleo Science, 50, pp. 21-28, 2001.
 
[17]  Suzuki, A., Fujii, A., Yamamoto, N., Yamamoto, M., Ohminami, H., Kameyama, A., Shibuya, Y., Nishizawa, Y., Tokimitsu, I., Saito, I,. “Improvement of hypertension and vascular dysfunction by hydroxyhydroquinone-free coffee in a genetic model of hypertension”, FEBS Letters, 580, pp. 2317-2322, 2006.
 
[18]  Yamaguchi, T., Chikama, A., Mori, K., Watanabe, T., Shioya, Y., Katsuragi, Y., Tokimitsu, I, “Hydroxyhydroquinone-free coffee: A double-blind, randomized controlled dose-response study of blood pressure”, Nutrition Metabolism and Cardiovascular Diseases, 18, pp. 408-414, 2008.
 
[19]  Ceriello, A, “Postprandial hyperglycemia and diabetes complications: Is it time to treat?” Diabetes, 54, pp. 1-7, 2005.
 
[20]  Ochiai, R., Nagao, T., Katsuragi, Y., Tokimitsu, I., Funatsu, K., Nakamura, H. “Effects of hydroxyhydroquinone-reduced coffee in patients with essential hypertension”, Journal of Health Science, 54, pp. 302-309, 2008.
 
[21]  Ochiai, R., Chikama, A., Kataoka, K., Tokimitsu, I., Maekawa, Y., Ohishi, M., Rakugi, H., Mikami, H. “Effects of hydroxyhydroquinone-reduced coffee on vasoreactivity and blood pressure” Hypertension Research, 32, pp. 969-974, 2009.
 
[22]  Hashimoto, S., Mizutani, E., Suzuki, M., Yoshida, A., Naito, M, “Effects of aerobic exercise on postprandial carbohydrate and lipoprotein metabolism following cookie ingestion in healthy young women” Journal of Nutritional Science and Vitaminology, 61, pp. 299-305, 2015.
 
[23]  Valavanidis, A., Vlachogianni, T., Fiotakis, CJ, “8-hydroxy-2' -deoxyguanosine (8-OHdG): A critical biomarker of oxidative stress and carcinogenesis” Journal of Environmental Science and Health Part C Environmental Carcinogenesis & Ecotoxicology Reviews, 27, pp. 120-139, 2009.
 
[24]  Johnston, KL., Clifford, MN., Morgan, LM, “Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: Glycemic effects of chlorogenic acid and caffeine”, The America Journal of Clinical Nutrition, 78, pp. 728-733, 2003.
 
[25]  Ochiai, R., Sugiura, Y., Shioya, Y., Otsuka, K., Katsuragi, Y,. Hashiguchi, T, “Coffee polyphenols improve peripheral endothelial function after glucose loading in healthy male adults”, Nutrition Research, 34, pp. 155-159, 2014.
 
[26]  Paravicini, TM., Touyz, RM, “NADPH oxidases, reactive oxygen species, and hypertension: clinical implications and therapeutic possibilities”, Diabetes Care, 31, pp. S170-S180, 2008.
 
[27]  Suzuki, A., Fujii, A., Jokura, H., Tokimitsu, I., Hase, T., Saito, I, “Hydroxyhydroquinone interferes with the chlorogenic acid-induced restoration of endothelial function in spontaneously hypertensive rats”, American Journal of Hypertension 21, pp. 23-27, 2008.