Fucoxanthin-Rich Brown Algae Extract Decreases Inflammation and Attenuates Colitis-associated Colon Cancer in Mice

Zwe-Ling Kong^1, , Ning-Jo Kao¹, Jia-Yuan Hu¹ and Chien-Sheng Wu¹

¹Department of Food Science, National Taiwan Ocean University, Keelung, Taiwan

Cite this paper:
Zwe-Ling Kong, Ning-Jo Kao, Jia-Yuan Hu and Chien-Sheng Wu. Fucoxanthin-Rich Brown Algae Extract Decreases Inflammation and Attenuates Colitis-associated Colon Cancer in Mice. Journal of Food and Nutrition Research. 2016; 4(3):137-147. doi: 10.12691/jfnr-4-3-2

Abstract

Fucoxanthin is a natural carotenoid that is isolated from seaweed. We evaluated the effects of fucoxanthin-rich brown algae extract (FX-BAE) on the development of dextran sulfate sodium (DSS)-induced colitis, and colitis-associated colon cancer (CACC) in BALB/c mice. Colitis mice were given drinking water containing 3% DSS for 14 days, and fed with or without FX-BAE (1, 2.5, or 5 g/kg bodyweight/day) from day 8 to day 14. Another way, CACC mice were treated with azoxymethane (AOM) and 2% DSS, and fed with or without FX-BAE at 0.5, 1, or 2.5 g/kg every 2 days. Results revealed the disease activity index (DAI), nitric oxide (NO), malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) were all significantly less in FX-BAE treated mice. Additionally, FX-BAE not only decreased the incidence of colonic neoplasm, but also increased superoxide dismutase (SOD) production, lymphocyte proliferation and survival rate in CACC mice.

Keywords:
fucoxanthin colitis colon cancer inflammation dextran sulfate sodium

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