Ethanol Extract of Polygonatumofficinale Rhizome Inhibits Odorant-Induced Camp and Calcium Levels in Non-Chemosensory 3T3-L1 Cells

Yeo Cho Yoon¹, Sung-Hee Kim¹, Jin-Taek Hwang¹, Mi Jeong Sung¹, Myung-Sunny Kim¹, Haeng Jeon Hur¹, Mee Ra Rhyu¹ and Jae-Ho Park^1,

¹Korea Food Research Institute, 1201-62 Anyangpangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, Republic of Korea

Cite this paper:
Yeo Cho Yoon, Sung-Hee Kim, Jin-Taek Hwang, Mi Jeong Sung, Myung-Sunny Kim, Haeng Jeon Hur, Mee Ra Rhyu and Jae-Ho Park. Ethanol Extract of Polygonatumofficinale Rhizome Inhibits Odorant-Induced Camp and Calcium Levels in Non-Chemosensory 3T3-L1 Cells. Journal of Food and Nutrition Research. 2014; 2(11):776-780. doi: 10.12691/jfnr-2-11-3

Abstract

Polygonatum Officinalerhizome, a member of the liliaceae family, is commonly consumed as tea in Asia. It is also clinically used to treat obesity and fatigue in Korean traditional medicine. Although the anti-diabetic effect of POR has been described, little is known about its physiological role in the olfactory system. In this study, we investigated the effects of POR in 3T3-L1 cells expressing an odorant receptor. We have shown that the levels of cAMP and Ca²⁺ and the phosphorylation of Rap1A and CREB increased in response to an odorant, eugenol. POR significantly decreased the eugenol-induced increase in cAMP and Ca²⁺. Taken together, these data suggest that POR inhibits an odorant-induced signal transduction pathway.

Keywords:
cAMP adenylyl cyclase olfactory polygonatumofficinale 3T3-L1

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