Effects of a Multi-Ingredient Dietary Supplement on Sexual Well-Being in Healthy Men: A Retrospective Analysis of a Randomized, Double-Blind, Placebo-Controlled Crossover Product-Monitoring Study

Xuan Li¹, Kazuya Watabe¹, Maya Sakashita¹, Aoi Tamura¹, Wako Ikeda¹, Saki Shirako¹, Kenji Sato¹ and Young-il Kim^1,

¹Pharma Foods International Co., Ltd., Kyoto 615-8245, Japan

Cite this paper:
Xuan Li, Kazuya Watabe, Maya Sakashita, Aoi Tamura, Wako Ikeda, Saki Shirako, Kenji Sato and Young-il Kim. Effects of a Multi-Ingredient Dietary Supplement on Sexual Well-Being in Healthy Men: A Retrospective Analysis of a Randomized, Double-Blind, Placebo-Controlled Crossover Product-Monitoring Study. Journal of Food and Nutrition Research. 2026; 14(9):185-194. doi: 10.12691/jfnr-14-9-1

Abstract

The present study retrospectively evaluated data from a product-monitoring test of a multi-ingredient dietary supplement containing egg white hydrolysate (EWH) as a principal bioactive component, together with maca extract, zinc, and other functional ingredients. The test involved healthy adult men aged 20–60 years and used a randomized, double-blind, placebo-controlled crossover procedure. Participants received the investigational product and placebo during separate two-week periods, with a one-week washout between periods. Sexual well-being and physical fatigue were assessed using self-reported visual analog scale (VAS) questionnaires after one and two weeks of each monitoring period. Nineteen participants entered the randomized monitoring sequences, and complete data from 16 participants were available for the principal analysis. Compared with placebo, use of the investigational product was associated with significantly higher scores for multiple endpoints of sexual well-being, including morning erection quality, erection hardness, erection maintenance, sexual desire, and sexual satisfaction. Favorable differences were also observed in fatigue-related measures. No serious adverse events were recorded during the monitoring periods. Overall, retrospective analysis of this product-monitoring dataset identified consistent treatment-associated patterns in self-reported sexual well-being, supporting further prospective evaluation of this EWH-containing multi-ingredient formulation.

Keywords:
dietary supplement product monitoring sexual well-being fatigue peptide egg white hydrolysate

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