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Tian, Y., Zhou, Q., Li, W., Liu, M., Li, Q. and Chen, Q., “Efficacy of L-arginine and Pycnogenol® in the treatment of male erectile dysfunction: a systematic review and meta-analysis,” Frontiers in Endocrinology, 14, 1211720, 2023.

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Article

Effects of a Multi-Ingredient Dietary Supplement on Sexual Well-Being in Healthy Men: A Retrospective Analysis of a Randomized, Double-Blind, Placebo-Controlled Crossover Product-Monitoring Study

1Pharma Foods International Co., Ltd., Kyoto 615-8245, Japan


Journal of Food and Nutrition Research. 2026, Vol. 14 No. 9, 185-194
DOI: 10.12691/jfnr-14-9-1
Copyright © 2026 Science and Education Publishing

Cite this paper:
Xuan Li, Kazuya Watabe, Maya Sakashita, Aoi Tamura, Wako Ikeda, Saki Shirako, Kenji Sato, Young-il Kim. Effects of a Multi-Ingredient Dietary Supplement on Sexual Well-Being in Healthy Men: A Retrospective Analysis of a Randomized, Double-Blind, Placebo-Controlled Crossover Product-Monitoring Study. Journal of Food and Nutrition Research. 2026; 14(9):185-194. doi: 10.12691/jfnr-14-9-1.

Correspondence to: Young-il  Kim, Pharma Foods International Co., Ltd., Kyoto 615-8245, Japan. Email: youngil-kim@pharmafoods.co.jp

Abstract

The present study retrospectively evaluated data from a product-monitoring test of a multi-ingredient dietary supplement containing egg white hydrolysate (EWH) as a principal bioactive component, together with maca extract, zinc, and other functional ingredients. The test involved healthy adult men aged 20–60 years and used a randomized, double-blind, placebo-controlled crossover procedure. Participants received the investigational product and placebo during separate two-week periods, with a one-week washout between periods. Sexual well-being and physical fatigue were assessed using self-reported visual analog scale (VAS) questionnaires after one and two weeks of each monitoring period. Nineteen participants entered the randomized monitoring sequences, and complete data from 16 participants were available for the principal analysis. Compared with placebo, use of the investigational product was associated with significantly higher scores for multiple endpoints of sexual well-being, including morning erection quality, erection hardness, erection maintenance, sexual desire, and sexual satisfaction. Favorable differences were also observed in fatigue-related measures. No serious adverse events were recorded during the monitoring periods. Overall, retrospective analysis of this product-monitoring dataset identified consistent treatment-associated patterns in self-reported sexual well-being, supporting further prospective evaluation of this EWH-containing multi-ingredient formulation.

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