Evaluation of GLP-1 Secretion Enhancement by Fermented Taiwan Citrus Peel in STC-1 Cells

Ho-Shin Huang^1, , Jyh-Perng Wang², Shih-Hong Chen², Zhe-Yu Jiang², Si-Ting Lin¹, Chun-Mei Lu¹ and Ting-Yuan Hsu³

¹Bio-Ray Biotech, INC, No. 21-3, Shennong E. Rd., Changzhi, Pingtung, Taiwan

²Animal Technology Research Center, Agricultural Technology Research Institute, No.52, Kedong 2nd Rd., Zhunan Township, Miaoli County, Taiwan

³R&D Center, Kao-Ho Hospital, No. 460, Bo'ai 1st Rd., Gushan Dist, Kaohsiung City, Taiwan

Cite this paper:
Ho-Shin Huang, Jyh-Perng Wang, Shih-Hong Chen, Zhe-Yu Jiang, Si-Ting Lin, Chun-Mei Lu and Ting-Yuan Hsu. Evaluation of GLP-1 Secretion Enhancement by Fermented Taiwan Citrus Peel in STC-1 Cells. Journal of Food and Nutrition Research. 2025; 13(3):140-145. doi: 10.12691/jfnr-13-3-3

Abstract

This study using HPLC tandem mass investigates the contents of main flavonoid compounds in fermented peel of Taiwan Citrus with Lactic acid bacteria. The results showed hesperidin, nobiletin and tangeretin were the main flavonoid compounds in fermented peel of Citrus taiwanica (FCT). In contrast, eriocitrin and hesperidin were most abundant bioactivity compounds in fermented peel of Citrus limon (FLP07). In this study, we investigated the effect of fermented citrus peel (FCT and FLP07) on Glucagon-like peptide-1(GLP-1) secretion in STC-1 cells, a well-established enteroendocrine cell model. The results showed FCT and FLP07 at all tested concentrations induced significantly higher GLP-1 secretion and suggest that FCT and FLP07 are more potent than serotonin in stimulating GLP-1 release, highlighting their potential as functional ingredients for metabolic health applications.

Keywords:
fermented citrus peel flavonoid Glucagon-like peptide-1 metabolic associated fatty liver disease

This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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