Research on the Mechanism of CHDH in the Metastasis of Colorectal Cancer

Bin Tang¹, Ying Hu¹, Ming-Bo Luo¹ and Jian-Ping Lia^1,

¹The Third Affiliated Hospital of Zunyi Medical University, The First People's Hospital of Zunyi, Department of neurocritical care, Zunyi, Guizhou, 563000, China.

Cite this paper:
Bin Tang, Ying Hu, Ming-Bo Luo and Jian-Ping Lia. Research on the Mechanism of CHDH in the Metastasis of Colorectal Cancer. Journal of Food and Nutrition Research. 2023; 11(10):646-651. doi: 10.12691/jfnr-11-10-6

Abstract

Colorectal cancer (CRC) is currently one of the most serious types of cancer in the world, with one of the highest morbidity and mortality rates of all cancers. Such a high fatality rate makes CRC a research hotspot in recent years. Cancer metastasis is one of the main reasons leading to the high mortality rate of cancer, CRC is no exception, CRC is very easy to develop liver metastasis, nearly half of the patients will suffer from liver metastasis. Therefore, the transfer of CRC was studied in this study. Choline dehydrogenase is a vital enzyme in the human body, and its metabolites can act as carbon units in carbon metabolism. Previous research has shown that CHDH is a breast cancer marker. As a result, the involvement of the Choline Dehydrogenase (CHDH ) gene in CRC metastasis was investigated in this work. The findings indicated that CHDH might influence colorectal cancer invasion and migration by influencing the Epithelial-mesenchymal Transition (EMT) process of CRC. Abbreviations: CRC = Colorectal Cancer, CHDH = Choline Dehydrogenase, EMT = Epithelial-mesenchymal Transition, FDA = Food and Drug Administration, SEPT9 = Receiver Operating Characteristic, NDRG4 = NDRG4 (Human) Recombinant Protein, BMP3 = Bone Plasticin 3, DMEM = dulbecco's modified eagle medium, FBS = Fetal Bovine Serum

Keywords:
choline dehydrogenase colorectal cancer Epithelial-Mesenchymal transition

This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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