Bin Tang¹, Ying Hu¹, Ming-Bo Luo¹, Jian-Ping Lia^1,

Colorectal cancer (CRC) is currently one of the most serious types of cancer in the world, with one of the highest morbidity and mortality rates of all cancers. Such a high fatality rate makes CRC a research hotspot in recent years. Cancer metastasis is one of the main reasons leading to the high mortality rate of cancer, CRC is no exception, CRC is very easy to develop liver metastasis, nearly half of the patients will suffer from liver metastasis. Therefore, the transfer of CRC was studied in this study. Choline dehydrogenase is a vital enzyme in the human body, and its metabolites can act as carbon units in carbon metabolism. Previous research has shown that CHDH is a breast cancer marker. As a result, the involvement of the Choline Dehydrogenase (CHDH ) gene in CRC metastasis was investigated in this work. The findings indicated that CHDH might influence colorectal cancer invasion and migration by influencing the Epithelial-mesenchymal Transition (EMT) process of CRC. Abbreviations: CRC = Colorectal Cancer, CHDH = Choline Dehydrogenase, EMT = Epithelial-mesenchymal Transition, FDA = Food and Drug Administration, SEPT9 = Receiver Operating Characteristic, NDRG4 = NDRG4 (Human) Recombinant Protein, BMP3 = Bone Plasticin 3, DMEM = dulbecco's modified eagle medium, FBS = Fetal Bovine Serum

choline dehydrogenase, colorectal cancer, Epithelial-Mesenchymal transition