The Effects of Lycopene Intake on Blood Pressure and Lipid Profile of Patients with Metabolic Syndrome; a Randomized Clinical Trial

Mahdi Mirahmadi¹, Malihe Aghasizadeh², Habibollah Esmaily^{3, 4}, Hamed Baharara⁵, Maryam Mohammadi-bajgiran², Reza Assaran-Darban⁶, Gordon A. Ferns⁷, Farzin Hadizaheh^{1, 8,} and Majid Ghayour Mobarhan^2,

¹Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran

²International UNESCO center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran

³Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

⁴Department of Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran

⁵Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran

⁶Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran

⁷Brighton & Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN19PH, UK

⁸Department of Medicinal Chemistry, School of Pharmacy, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran

Cite this paper:
Mahdi Mirahmadi, Malihe Aghasizadeh, Habibollah Esmaily, Hamed Baharara, Maryam Mohammadi-bajgiran, Reza Assaran-Darban, Gordon A. Ferns, Farzin Hadizaheh and Majid Ghayour Mobarhan. The Effects of Lycopene Intake on Blood Pressure and Lipid Profile of Patients with Metabolic Syndrome; a Randomized Clinical Trial. Journal of Food and Nutrition Research. 2023; 11(9):602-607. doi: 10.12691/jfnr-11-9-7

Abstract

The lycopene has positively affect human health by reducing metabolic disorder, which is a mechanism behind metabolic syndrome (MetS). We developed a method for encapsulating lycopene and designed a randomized clinical trial to assess the effect of lycopene on lipid profile of patients with MetS. In this study, 80 subjects with MetS were randomly assigned to two groups: one group received lycopene at a dose of 30 mg (1 tablet per-day) for 8 weeks. The second group received placebo with similar color, size, and other appearance to lycopene tablets. Participants returned for follow-up visits after 4 and 8 weeks and blood samples were collected for examination of fasting blood glucose and lipid profile. These measurements were taken using an alpha-classic analyzer. The average age of the lycopene and placebo groups were 44.25±11.25 and 41.75 ±10.05 years, respectively. There were significant differences in systolic blood pressure (SBP), fasting blood glucose (FBG), low-density lipoprotein (LDL), total cholesterol (TC), and triglycerides (TG) in the lycopene group before and after treatment, but there was no significant effect of treatment in the placebo group. After adjusting for confounding factors such as age, sex, FBG, LDL, and TC as co-variant, the P value of difference between lycopene and placebo groups was significant. Traditionally, lycopene was found to significantly increase serum high-density lipoprotein (HDL) in patients with MetS. This research expands our knowledge about protective effects of lycopene on lipid profile, as an important risk factor for evaluating of cardiovascular disease.

Keywords:
metabolic syndrome lycopene lipid profile blood pressure

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