Journal of Food and Nutrition Research
ISSN (Print): 2333-1119 ISSN (Online): 2333-1240 Website: https://www.sciepub.com/journal/jfnr Editor-in-chief: Prabhat Kumar Mandal
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Journal of Food and Nutrition Research. 2022, 10(6), 409-414
DOI: 10.12691/jfnr-10-6-4
Open AccessArticle

The Relationship between Glycosylated Hemoglobin, Gestational Weight and Pregnancy Outcome in Patients with Gestational Diabetes

Zhou Xin1, , Lin Tong1, Zhang Qingye1 and Zhao Xia1

1Nutritional Department, Beijing Jishuitan Hospital, Beijing, China

Pub. Date: June 21, 2022

Cite this paper:
Zhou Xin, Lin Tong, Zhang Qingye and Zhao Xia. The Relationship between Glycosylated Hemoglobin, Gestational Weight and Pregnancy Outcome in Patients with Gestational Diabetes. Journal of Food and Nutrition Research. 2022; 10(6):409-414. doi: 10.12691/jfnr-10-6-4

Abstract

Purpose: To observe the relationship between the level of glycosylated hemoglobin (HbA1c) during pregnancy and the incidence of gestational diabetes mellitus (GDM) and the outcome of pregnancy in GDM patients. Methods: There were 334 pregnant women with GDM and 366 pregnant women with normal blood glucose selected into our research who had undergone regular check-ups and deliveries in our hospital from October 2018 to October 2019. Results: (1) Pregnant women with overweight and obesity before pregnancy have higher HbA1c in the first and third trimesters than those with normal and low weight before pregnancy (P<0.05). And the pregnancy of excessive weight gain during the second and third trimester and the total weight excessive gain pregnancy were statistically significant in HbA1c of third trimesters (P<0.05). (2) HbA1c in early pregnancy is a risk factor for the onset of GDM (OR=4.591, 95%CI 2.504-8.418). And the prediction critical point of GDM prediction of HbA1c in early pregnancy is 5.25%. (3) Logistic multivariate regression analysis found that HbA1c in the third trimester of pregnancy was the risk factor of adverse outcome of pregnancy including hypertensive disorders of pregnancy (OR=3.997, 95%CI 1.697-9.411), cesarean section (OR=2.024, 95%CI 1.179-3.474), and macrosomia (OR=2.261, 95%CI 1.198-4.267). Conclusion: The detection of HbA1c in early pregnancy helps to screen high-risk pregnancy of GDM and intervene them earlily. And HbA1c in the third trimester can help predict adverse pregnancy outcomes.

Keywords:
glycosylated hemoglobin gestational diabetes mellitus adverse pregnancy outcome

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