Global Journal of Surgery
ISSN (Print): 2379-8742 ISSN (Online): 2379-8750 Website: Editor-in-chief: Baki Topal
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Global Journal of Surgery. 2017, 5(1), 17-19
DOI: 10.12691/js-5-1-6
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Gallbladder Cancer in Sudan: A Two-centre Study

Walid Elhaj Abdelrahim1, , Kamal Elzaki Elsiddig1, Mohamed Elhassan Akoad2, Mohamed Abbas1 and Eltahir AG Khalil3

1Department of Surgery, Faculty of Medicine, University of Khartoum, Sudan

2Department of Transplantation, Lahey Clinic, Tufts University, USA

3Department of Clinical Pathology & Immunology, Institute of Endemic Diseases, University of Khartoum, Sudan

Pub. Date: December 18, 2017

Cite this paper:
Walid Elhaj Abdelrahim, Kamal Elzaki Elsiddig, Mohamed Elhassan Akoad, Mohamed Abbas and Eltahir AG Khalil. Gallbladder Cancer in Sudan: A Two-centre Study. Global Journal of Surgery. 2017; 5(1):17-19. doi: 10.12691/js-5-1-6


Poor prognosis of gallbladder cancer (GBC) is due to delayed presentation. Female gender and gallstones are important risk factors. Surgical resection offers significant improvement in 5 year actuarial survival. In Sudan, proper imaging modalities and professional multi-disciplinary teams are available but, inter-disciplinary management protocols haven't been established. This paper aims to delineate the patterns of presentation, possible risk factors and the natural history of GBC to guide management practices in resource-limited settings. The records of 106 patients from two tertiary referral centres were examined. Inclusion criteria included: radiological features of gallbladder mass in addition to one of the following: liver metastasis, porta hepatis lymphadenopathy and/or ascites. The majority of patients were females (70.5%) with a mean age of 64.27¡À11.39 years with median duration of symptoms of 3 months. The main presenting symptoms were: loss of weight (39.2%), abdominal swelling (35.8%), obstructive jaundice (31.1%) and vomiting (17.6%). Cholelithiasis as detected by ultrasound/CT/MRI was reported in most cases (75.4%). Liver metastasis, biliary dilatation and lymphadenopathy were seen in 67.2%, 40.3% and 39% respectively. Open simple cholecystectomy was performed in a quarter of the patients (24.5%), none had re-resection after postoperative diagnosis of GBC. No significant 3 and 6 months survival benefits were observed in the simple cholecystectomy group compared to those who didn¡¯t (p=0.8 and 0.2 respectively). More than fifty per cent (51.1%) of patients received chemotherapy, with no 3 and 6 months survival benefits. The main causes of death were obstructive jaundice complicated by cholangitis and gastric outlet obstruction in 69.5% and 30.5% of patients respectively. The overall survival of CBC patients was 4.96¡À12.5 months. Most patients presented late, the majority had unrespectable disease, very short duration of symptoms and poor survival. Patients with advanced disease should have holistic palliative approach via a multi-discilpinary team together with systemic chemotherapy.

gall bladder cancer simple cholecystectomy chemotherapy cholelithiasis

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