Effect of G₆pd Status in Malaria Infected Individuals on Cortisol, Malondialdehyde, Blood Glucose and Blood Lipid Profile

Esan A.J^1, and Ifeanyichukwu M.O²

¹Haematology Department, Federal Medical Centre, Ido-Ekiti, Ekiti State Nigeria

²Immunology Department, Nnamidi Azikiwe University, Nnewi Campus

Cite this paper:
Esan A.J and Ifeanyichukwu M.O. Effect of G₆pd Status in Malaria Infected Individuals on Cortisol, Malondialdehyde, Blood Glucose and Blood Lipid Profile. International Journal of Hematological Disorders. 2014; 1(1):31-34. doi: 10.12691/ijhd-1-1-6

Abstract

The aim of this study was to determine the effect of Glucose-6-Phosphate dehydrogenase (G6PD) status in Plasmodium falciparum malaria infected individuals cortisol, malondialdehyde (MDA), blood glucose and blood lipid profile. The study was conducted at Federal Medical Centre, Ido-Ekiti, Nigeria. Two hundred and two blood samples were collected twice from each malaria infected individuals. Thick blood film was made and stained with Giemsa’s staining technique for malaria parasite detection; Glucose-6-Phosphate dehydrogenase (G-6-PD) was performed using methaemoglobin reduction method. Data obtained was analysed using SPSS version 16. The result of this present study showed that the mean±SD of cortisol and malondialdehyde (MDA) in G6PD normal were higher compared to G6PD deficient in pre and post anti-malaria drug treatment. Cortisol levels increased in patients with P.falciparum malaria infection, which decline as the clinical condition improved and parasitaemia decrease during anti malaria treatment.

Keywords:
malaria parasite G₆PD and anti-malaria therapy

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