International Journal of Clinical Nutrition
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International Journal of Clinical Nutrition. 2014, 2(2), 32-35
DOI: 10.12691/ijcn-2-2-2
Open AccessArticle

Effect of Ginger (Zingiber Officinale) Extracts on Blood Glucose in Normal and Streptozotocin--Induced Diabetic Rats

ADENIYI Paulina Oludoyin1, 2, and SANUSI Rasaki Adegoke1

1University of Ibadan, Ibadan, Nigeria

2Institute of Agricultural Research and Training, Apata, Ibadan, Nigeria

Pub. Date: July 02, 2014

Cite this paper:
ADENIYI Paulina Oludoyin and SANUSI Rasaki Adegoke. Effect of Ginger (Zingiber Officinale) Extracts on Blood Glucose in Normal and Streptozotocin--Induced Diabetic Rats. International Journal of Clinical Nutrition. 2014; 2(2):32-35. doi: 10.12691/ijcn-2-2-2


The increasing global prevalence of diabetes mellitus requires a holistic approach which is easy and cheap to apply for acceptability and affordability by all categories of people, hence, the use of spices to combat this social ill needs to be explored. In view of this, this study aimed at determining the effect of raw and cooked ginger juice on blood glucose in normal and streptozotocin-induced diabetic rats as a first phase of experimental study of its possible use as an anti diabetic food adjunct in human subjects. Male Albino rats (70) of weight range 143-180 g were divided into 7 groups and were treated thus: NT1S- normal control, NT1R- normal rats given 4 ml/kg body weight raw ginger juice, NT1Co- normal rats given cooked ginger juice, T1S- diabetic control, T1R- diabetic rats given raw ginger juice, T1Co- diabetic rats given cooked ginger juice and T1D- diabetic rats given glibenclamide (5 mg/kg body weight). Fasting blood glucose (FBG) was taken from overnight fasted rats before and after diabetes was induced (with 60 mg/kg body weight intra peritoneal injection) and at the end of the second and fourth weeks of ginger administration using ACCUCHEK Active Glucometer, Roche, Germany. ANOVA and Least Significant Difference were used for statistical analyses. The FBG was reduced to normal by raw and cooked ginger extracts and glibenclamide (p<0.05) in diabetic rats while it was significantly lower than normal (p< 0.05) in normal rats given ginger extracts. There was no significant difference (p< 0.05) between FBG in normal rats given raw ginger and cooked ginger extracts. It can be inferred from this study that the active hypoglycemic component of ginger was not affected by heat, hence, the consumption of ginger in raw and cooked forms in different cuisines may be an effective regimen in the management of diabetes. Also, consumption of ginger by normal subjects may not cause hypoglycemia but further study is recommended in this area.

Raw ginger cooked ginger blood glucose diabetes

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[1]  Amos A., McCarty D. and Zimmet P. (1997). The rising global burden of diabetes and its complications: estimates and projections to the year 2010. Diabetic Med. ;14: S1-S85
[2]  Zimmet P., Shaw J and Albert K.G. (2003). Preventing Type 2 diabetes and the dysmetabolic syndrome in the real world: a realistic review. Diabet. Med.; 20: 693-702
[3]  Wild S., Roglic G., Green A., Sicree R and King H. (2004). Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030. Diabetes Care; 27 (5): 1047-1053.
[4]  Guariguata L., Whiting D.R., Humbleton I., Beagley J.,Linnenkamp U and Shaw J.E. (2014). Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Research and Clinical Practice; 103 (2): 137-149.
[5]  Srinivasan K. (2005). Plant foods in the management of diabetes mellitus: Spices as beneficial anti diabetic food adjunct. International Journal of Food Science and Nutrition; 56 (6): 399-414.
[6]  Grant K.I. (2000). Ginger. Am. J. Health Sys. Pharm.; 57: 945-957.
[7]  Ursell A. (2000). The complete guide to healing foods: pp 112-114, Dorling Kindersley Ltd, London.
[8]  Portnoi G., Chng L.A., Karimi-Tabesh L., Koren G., Tan M.P. and Einarson A. (2003). Prospective comparative study of the safety and effectiveness of ginger for the treatment of nausea and vomiting in pregnancy. Am J. Obstet. Gynaecol.; 189: 1374-1377.
[9]  Suekawa M., Ishige A., Yuansa K., Sudo K., Aburada M. and Hosoya E. (1984). Pharmacological studies on ginger- Pharmacological actions of pungent constituents of 6-gingerol and 6-shogaol. J. Pharmacoblodyn; 7: 836-848.
[10]  Ojewole J.A.O. (2006). Analgesic, anti-inflammatory and hypoglycemic effects of ethanol extract of Zingiber officinale (Roscoe) rhizomes in mice and rats. Phytotherapy Research; 20: 764-772.
[11]  Young H.V., Luo Y.L., Chang H.Y., HaiehW.C. Liao J.C. and Peng W.C. (2005). Analgesic and anti-inflammatory activities of 6-gingerol. J. Ethnopharmacol.; 96: 207-210.
[12]  Mascolo N., Jain R.Jain S.C. and Capasso F. (1989). Ethno pharmacologic investigation of ginger (Zingiber officinale). J. Ethnopharmacol.; 27: 129-140.
[13]  Ghayur M.N. and Gilani A.H. (2005). Ginger lowers blood pressure through blockade of voltage-dependent calcium channels. J. Cardiosvasc. Pharmacol. 45: 74-80.
[14]  Al-Amin Z.M., Thomson M., Al-Qattan K.K., Peltonen-Shalaby R., and Ali M. (2006). Anti diabetic and hypoglycemic properties of ginger (Zingiber officinale) in streptozotocin-induced diabetic rats. British Journal of Nutrition; 96: 660-666.
[15]  Bordia A.,Verma S.K. and Srivastava K.C. (1997). Effect of ginger (Zingiber officinale Rosc.) and fenugreek (Trigonella foenumgraecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease. Prostaglandins Leukotrienes and Essential fatty acids; 56 (5): 379-384.
[16]  Arablou T., Aryaeian N., Valizadeh M., Shariffi F., Hosseini A and Djalali M. (2014). The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with Type 2 diabetes mellitus. International Journal of Food Sciences and Nutrition; 65 (4): 515-520.
[17]  Mozaffari-Khosravi H., Talaei B., Jalali B-A., Najarzadeh A and Mozayan M.R. (2014). The effect of ginger powder supplementation on insulin resistance and glycemic indices in patients with Type 2 diabetes: A randomized double-blind placebo-controlled trial. Complementary Therapies in Medicine; 22 (1): 9-16.
[18]  Son M.J., Miura Y and Kazum Y. (2014). Mechanism of anti diabetic effect of gingerol in cultured cultured cells and obese diabetic model mice. Cytotechnology.
[19]  Mahluji S., Attari V.E., Mabassori M., Payahoo L., Ostadrahimi A and Golzari S.E.J. (2013). Effect of ginger (Zingiber officinale) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients. International Journal of Food Sciences and Nutrition; 64 (6): 682-686.
[20]  Sukalingam K., Ganesan K. and Gani S.B. (2013). Hypoglycemic effect of 6-gingerol, an active principle of ginger in streptozotocin-induced diabetic rats. Journal of Pharmacology and Toxicological Studies; 1 (2): 23-30.
[21]  Abdulrazaq N.B., Cho M.M., Win N.N., Zaman R. and Rahman M.T. (2012). Beneficial effects of ginger (Zingiber officinale) on carbohydrate metabolism in streptozotocin-induced diabetic rats. British Journal of Nutrition; 108 (7): 1194-1201.
[22]  Jafri S.A., Abass S. and Qasim M. (2011). Hypoglycemic effect of Ginger (Zingiber officinale) in alloxan-induced diabetic rats (Rattus norvagicus). Pakistan Veterinary Journal; 31 (2): 160-162.
[23]  Elshater A.A., Salman M.M.A and Moussa M.M.A. (2009) Effect of Ginger extract consumption on levels of blood glucose, lipid profile and kidney functions in alloxan-induced diabetic rats. Egypt Acad. J. Biol. Sci.; 2 (1): 153-162.