Role of the Microbiome in Celiac Disease

Nóra Judit Béres¹, Erna Sziksz^{1, 2}, Ádám Vannay^{1, 2}, Dolóresz Szabó¹, Domonkos Pap^{1, 2}, Apor Veres-Székely^{1, 2}, András Arató¹, Attila J. Szabó^{1, 2} and Gábor Veres^1,

¹Department of Pediatrics, Semmelweis University, H-1083, Budapest, Hungary

²MTA-SE,Pediatrics and Nephrology Research Group, H-1083, Budapest, Hungary

Cite this paper:
Nóra Judit Béres, Erna Sziksz, Ádám Vannay, Dolóresz Szabó, Domonkos Pap, Apor Veres-Székely, András Arató, Attila J. Szabó and Gábor Veres. Role of the Microbiome in Celiac Disease. International Journal of Celiac Disease. 2014; 2(4):150-153. doi: 10.12691/ijcd-2-4-4

Abstract

Microbiome is the community of commensal, symbiotic and pathogenic microorganism that share our human body space. Intestinal microbiota has a defensive role in human health, it is implicated in metabolic and nutritional processes and plays an important role in the pathophysiology of several diseases. In recent years special attention has been paid to investigations targeting the changes of intestinal microbiome in various gastrointestinal disorders including inflammatory bowel disease, infectious colitis and celiac disease (CD). The aim of our present review is to summarize the role of the microbiome in CD and the changes of its composition in the intestine of patients suffering from CD.

Keywords:
microbiome intestinal microbiota celiac disease

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References:

[1]	Rosen A, Sandstrom O, Carlsson A, Hogberg L, Olen O, Stenlund H, et al. Usefulness of Symptoms to Screen for Celiac Disease. Pediatrics 2014; 133: 211-218.
[2]	Sziksz E., Vörös P., Veres G., Fekete A., Vannay Á. Coeliac Disease: From Triggering Factors to Treatment. International Journal of Celiac Disease 2013; 1: 9-13.
[3]	Toft-Hansen H, Nielsen C, Biagini M, Husby S, Lillevang ST. Lectin staining shows no evidence of involvement of glycocalyx/mucous layer carbohydrate structures in development of celiac disease. Nutrients 2013; 5: 4540-4552.
[4]	Kocsis D, Miheller P, Lorinczy K, Herszenyi L, Tulassay Z, Racz K, et al. Coeliac disease in a 15-year period of observation (1997 and 2011) in a Hungarian referral centre. European journal of internal medicine 2013; 24: 461-467.
[5]	Cheng J, Kalliomaki M, Heilig HG, Palva A, Lahteenoja H, de Vos WM, et al. Duodenal microbiota composition and mucosal homeostasis in pediatric celiac disease. BMC gastroenterology 2013; 13: 113.
[6]	Kocsis D, Beres N, Veres G, Szabo D, Muller KE, Arato A, et al. [Genetic and epigenetic aspects of celiac disease]. Orv Hetil 2014; 155: 83-88.
[7]	Biasucci G, Benenati B, Morelli L, Bessi E, Boehm G. Cesarean delivery may affect the early biodiversity of intestinal bacteria. The Journal of nutrition 2008; 138: 1796s-800s.
[8]	Bustos Fernandez LM, Lasa JS, Man F. Intestinal Microbiota: Its Role in Digestive Diseases. Journal of clinical gastroenterology 2014; 48: 657-666.
[9]	Di Gioia D, Aloisio I, Mazzola G, Biavati B. Bifidobacteria: their impact on gut microbiota composition and their applications as probiotics in infants. Applied microbiology and biotechnology. 2014; 98: 563-577.
[10]	Round JL, Mazmanian SK. The gut microbiota shapes intestinal immune responses during health and disease. Nature reviews Immunology 2009; 9: 313-323.
[11]	Vieira AT, Teixeira MM, Martins FS. The Role of Probiotics and Prebiotics in Inducing Gut Immunity. Frontiers in immunology 2013; 4: 445.
[12]	Flint HJ, Duncan SH, Scott KP, Louis P. Interactions and competition within the microbial community of the human colon: links between diet and health. Environmental microbiology 2007; 9: 1101-1111.
[13]	Sokol H, Pigneur B, Watterlot L, Lakhdari O, Bermudez-Humaran LG, Gratadoux JJ, et al. Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proceedings of the National Academy of Sciences of the United States of America 2008; 105: 16731-16736.
[14]	Rajpal DK, Brown JR. Modulating the human gut microbiome as an emerging therapeutic paradigm. Science progress 2013; 96: 224-236.
[15]	Dezsofi A, Szebeni B, Hermann CS, Kapitany A, Veres G, Sipka S, et al. Frequencies of genetic polymorphisms of TLR4 and CD14 and of HLA-DQ genotypes in children with celiac disease, type 1 diabetes mellitus, or both. Journal of pediatric gastroenterology and nutrition 2008; 47: 283-287.
[16]	Goodman AL, Kallstrom G, Faith JJ, Reyes A, Moore A, Dantas G, et al. Extensive personal human gut microbiota culture collections characterized and manipulated in gnotobiotic mice. Proceedings of the National Academy of Sciences of the United States of America 2011; 108: 6252-6257.
[17]	Major G, Spiller R. Irritable bowel syndrome, inflammatory bowel disease and the microbiome. Current opinion in endocrinology, diabetes, and obesity 2014; 21: 15-21.
[18]	Chakravorty S, Helb D, Burday M, Connell N, Alland D. A detailed analysis of 16S ribosomal RNA gene segments for the diagnosis of pathogenic bacteria. Journal of microbiological methods 2007; 69: 330-339.
[19]	Nadal I, Donat E, Ribes-Koninckx C, Calabuig M, Sanz Y. Imbalance in the composition of the duodenal microbiota of children with coeliac disease. Journal of medical microbiology. 2007 56: 1669-74.
[20]	De Palma G, Nadal I, Collado MC, Sanz Y. Effects of a gluten-free diet on gut microbiota and immune function in healthy adult human subjects. The British journal of nutrition 2009; 102: 1154-1160.
[21]	Collado MC, Donat E, Ribes-Koninckx C, Calabuig M, Sanz Y. Specific duodenal and faecal bacterial groups associated with paediatric coeliac disease. Journal of clinical pathology 2009; 62: 264-269.
[22]	Lupan I, Sur G, Deleanu D, Cristea V, Samasca G, Makovicky P. et al. Celiac disease microbiota and its applications. Ann Microbiol 2013; 64: 899-903.
[23]	Olivares M, Castillejo G, Varea V, Sanz Y. Double-blind, randomised, placebo-controlled intervention trial to evaluate the effects of Bifidobacterium longum CECT 7347 in children with newly diagnosed coeliac disease. The British journal of nutrition 2014; 112: 30-40.
[24]	Forsberg G, Fahlgren A, Horstedt P, Hammarstrom S, Hernell O, Hammarstrom ML. Presence of bacteria and innate immunity of intestinal epithelium in childhood celiac disease. The American journal of gastroenterology 2004; 99: 894-904.
[25]	Sanchez E, Donat E, Ribes-Koninckx C, Fernandez-Murga ML, Sanz Y. Duodenal-mucosal bacteria associated with celiac disease in children. Applied and environmental microbiology 2013; 79: 5472-5479.
[26]	Lasa J, Zubiaurre I, Should Small Intestine Bacterial Overgrowth be Ruled out as a Cause of Non-Responsive Celiac Disease?: A Case Report. International Journal of Celiac Disease 2014; 2: 67-69.
[27]	Galatola G, Grosso M, Barlotta A, Ferraris R, Rovera L, Ariano M, et al. [Diagnosis of bacterial contamination of the small intestine using the 1 g [14C] xylose breath test in various gastrointestinal diseases]. Minerva gastroenterologica e dietologica 1991; 37: 169-75.
[28]	Tursi A, Brandimarte G, Giorgetti G. High prevalence of small intestinal bacterial overgrowth in celiac patients with persistence of gastrointestinal symptoms after gluten withdrawal. The American journal of gastroenterology 2003; 98: 839-843.
[29]	Sellitto M, Bai G, Serena G, Fricke WF, Sturgeon C, Gajer P, et al. Proof of concept of microbiome-metabolome analysis and delayed gluten exposure on celiac disease autoimmunity in genetically at-risk infants. PloS one 2012; 7: e33387.
[30]	Palma GD, Capilla A, Nova E, Castillejo G, Varea V, Pozo T, et al. Influence of milk-feeding type and genetic risk of developing coeliac disease on intestinal microbiota of infants: the PROFICEL study. PloS one 2012; 7: e30791.