Comparative Study of the Effectiveness of Ginger for the Treatment of Nausea and Vomiting in Induced Pregnancy

Asatova M. M.¹, Voitova G. A.^1, and Saidazova Sh. Sh.¹

¹Tashkent Institute for Post-Graduate Medical Education, Tashkent, Uzbekistan

Cite this paper:
Asatova M. M., Voitova G. A. and Saidazova Sh. Sh.. Comparative Study of the Effectiveness of Ginger for the Treatment of Nausea and Vomiting in Induced Pregnancy. American Journal of Medical Sciences and Medicine. 2019; 7(1):1-5. doi: 10.12691/ajmsm-7-1-1

Abstract

Objective. The objective of our study was to examine the effectiveness of ginger for nausea and vomiting of induced pregnancy (NVIP). Methods. In a clinical trial in perinatal center of the Tashkent Institute for Post-Graduate Medical Education from 2009 to 2017 on pregnant women after ovulation induction, the effects of ginger (240 mg four times daily), vitamin B 6 (40 mg twice daily) and metoclopramide were evaluated in treatment of NVIP. Results. In all groups, treatments led to reduction in PUQE-24 score. Scores of symptoms before treatment in ginger group were 10,8±2,03, in vitamin B6 - 9,48±2,4 and metoclopramide - 9,52±2,4, and reduced to 4,23±1.1, 8.23±1.1 and 7.43±1.2, respectively, in the sixth day of treatment; however, mean changes in the two groups were not significantly different. Conclusion. Vomiting was more reduced in ginger group and this reduction was statistically significant. There was significant difference between the groups in nausea occurrences and their duration. No side effect was observed in studied groups.

Keywords:
induced pregnancy first trimester nausea and vomiting ginger

This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References:

[1]	Maltepe C, Koren G. The management of nausea and vomiting of pregnancy and hyperemesis gravidarum: a 2013 update. Journal of Population Therapeutics and Clinical Pharmacology. 2013; 20(2): 184-192.
[2]	Piwko C, Koren G, Babashov V, Vicente C, Einarson TR. Economic burden of nausea and vomiting of pregnancy in the USA. Journal of Population Therapeutics and Clinical Pharmacology. 2013; 20(2): 149-160.
[3]	Asker C, Wikner BN, Källén B. Use of antiemetic drugs during pregnancy in Sweden. European Journal of Clinical Pharmacology. 2005; 61(12): 899-906.
[4]	Borrelli F, Capasso R, Aviello G, Pittler MH, Izzo AA. Effectiveness and safety of ginger in the treatment of pregnancy-induced nausea and vomiting. Obstetrics and Gynecology. 2005; 105(4): 849-856.
[5]	Jewell D, Young G. WITHDRAWN: interventions for nausea and vomiting in early pregnancy. Cochrane database of systematic reviews (Online) 2010; 9CD000145.
[6]	Ding M, Leach M, Bradley H. The effectiveness and safety of ginger for pregnancy-induced Nausea and vomiting: a systematic review. Women and Birth. 2013; 26(1): 26-30.
[7]	Betz O, Kranke P, Geldner G, Wulf H, Eberhart LHJ. Is ginger a clinically relevant antiemetic? A systematic review of randomized controlled trials. Forschende Komplementarmedizin und Klassische Naturheilkunde. 2005; 12(1): 14-23.
[8]	Sripramote M, Lekhyananda N. A randomized comparison of Ginger and vitamin B6 in the treatment of nausea and vomiting of pregnancy. Journal of the Medical Association of Thailand. 2003; 86(9): 846-853.
[9]	Smith C, Crowther C, Willson K, Hotham N, McMillian V. A randomized controlled trial of ginger to treat nausea and vomiting in pregnancy. Obstetrics and Gynecology. 2004; 103(4): 639-645.
[10]	Portnoi G, Chng L-A, Karimi-Tabesh L, Koren G, Tan MP, Einarson A. Prospective comparative study of the safety and effectiveness of ginger for the treatment of nausea and vomiting in pregnancy. The American Journal of Obstetrics and Gynecology. 2003; 189(5): 1374-77.
[11]	Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. Journal of the Medical Association of Thailand. 2007; 90(1): 15-20.
[12]	Ensiyeh J, Sakineh M-AC. Comparing ginger and vitamin B6 for the treatment of nausea and vomiting in pregnancy: a randomised controlled trial. Midwifery. 2009; 25(6): 649-653.
[13]	Boone SA, Shields KM. Treating pregnancy-related nausea and vomiting with ginger. Annals of Pharmacotherapy. 2005; 39(10): 1710-1713.