American Journal of Medical Case Reports
ISSN (Print): 2374-2151 ISSN (Online): 2374-216X Website: http://www.sciepub.com/journal/ajmcr Editor-in-chief: Apply for this position
Open Access
Journal Browser
Go
American Journal of Medical Case Reports. 2018, 6(8), 152-156
DOI: 10.12691/ajmcr-6-8-2
Open AccessArticle

Genotypic Profile of Hepatitis C Virus (HCV) in Patients Attending the Medical Outpatient Department in Bingham University Teaching Hospital Jos Nigeria for Chronic HCV Infection

David Olorunfemi Samuel1, , Musa Bolanle Olufunke2 and Oyeleke Kikelomo Ganiyat3

1Department of Internal Medicine, College of Health Sciences, Bingham University, Jos Campus, Plateau State, Nigeria

2Ahmadu Bello University Teaching Hospital Shikka Kaduna State

3Department of Medicine, Lagos University Teaching Hospital, Lagos Nigeria

Pub. Date: August 23, 2018

Cite this paper:
David Olorunfemi Samuel, Musa Bolanle Olufunke and Oyeleke Kikelomo Ganiyat. Genotypic Profile of Hepatitis C Virus (HCV) in Patients Attending the Medical Outpatient Department in Bingham University Teaching Hospital Jos Nigeria for Chronic HCV Infection. American Journal of Medical Case Reports. 2018; 6(8):152-156. doi: 10.12691/ajmcr-6-8-2

Abstract

INTRODUCTION: HCV is recognized as the major cause of transfusion associated and sexually transmitted sporadic chronic non-A non-B hepatitis. There is a high degree of genetic variability from HCV genomes isolated from infected patients. Currently, HCV isolates are classified into at least six major genotypes and numerous sub- genotypes. The genetic diversity of HCV and the clinical and virological relevance of HCV genetic classification schemes remain important areas of active research. OBJECTIVES: The objective of this study was to determine the genotypic profile of hepatitis C virus (HCV) in patients who are infected with chronic HCV with or without liver cirrhosis and hepatocellular carcinoma, receiving treatment at the medical outpatient department (MOPD) of the Bingham University Teaching Hospital Jos Nigeria with a view to seeing which of these genotypes is more prevalent. METHODS: This prospective cohort study enrolled patients who were clinically diagnosed to have chronic HCV infection and subsequently confirmed by polymerase chain reaction (PCR) using the light cycler. Patients attending the clinic from December 2012 to December 2014 who had all the relevant investigations done were enrolled in the study. This was regardless of whether they were profiled for commencement of treatment or not due to disease stage. RESULTS: A total of 48 patients were enrolled for the study during the period. Out of this figure, genotype 1 patients accounted for 34 (70.8 %) to emerge the leading genotype in the centre. This was followed by genotype 4 with a very low value of 7(14.6 %) as the second while genotype 2 had 6 (12.5 %) and genotype 3 had only 1 (2.1 %) patient. CONCLUSION: The study has revealed that HCV genotype 1 is the most prevalent among the population studied followed by genotype 4 while other genotypes 2 and 3 were also encountered but with lesser prevalence.

Keywords:
viral hepatitis C chronic infection genotypes

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References:

[1]  Gashau W, Mohammed I. Hepatitis B virus markers in Nigerian patients with primary liver cell carcinoma. Trop Geog. Med. 1991; 43: 64-67.
 
[2]  Cooreman M P, Schoondermark-Van de Ven E M. Hepatitis C virus: biological and clinical consequences of genetic heterogeneity. Scand J Gastroenterol Suppl. 1996; 218: 106ā€“115.
 
[3]  National Institutes of Health Consensus Development Conference Panel. National Institutes of Health Consensus Development Conference Panel statement: management of hepatitis C. Hepatology. 1997; 26 (Suppl. 1):2Sā€“10S.
 
[4]  David SO, Ibinaiye PO and Bello BO. Evaluation of the Cost of Management of Chronic Viral Hepatitis B and C in Zaria Kaduna State Nigeria. European Journal of scientific Research. 2013; 101 (2): 292-296.
 
[5]  Abdulkarim A S, Zein N N, Germer J J, Kolbert C P, Kabbani L, Krajnik K L, Hola A, Agha M N, Tourogman M, Persing D H. Hepatitis C virus genotypes and hepatitis G virus in hemodialysis patients from Syria: identification of two novel hepatitis C virus subtypes. Am J Trop Med Hyg. 1998; 59: 571-576.
 
[6]  Strickland GT. Liver disease in Egypt: Hepatitis C superseded schistosomiasis as a result of iatrogenic and biological factors. Hepatology.2006 ; 43(5): 915-922.
 
[7]  Grace Rinmecit Pennap, Aliyu Yakubu, Odua Oyige and Joseph Forbi. Prevalence of hepatitis B and C virus infection among people of a local community in Keffi, Nigeria: African Journal of Microbiology Research .2010; 4 (4):274-278.
 
[8]  Ayolabi CI, Taiwo MA, Omilabu SA, Adebisi AO and Fatoba OM. Seroprevalence of hepatitis C virus among blood donors in Lagos Nigeria. African journal of Biotechnology .2006;.5 (20):1944-1946.
 
[9]  Chamberlain R W, Adams N, Saeed A A, Simmonds P, Elliott R M. Complete nucleotide sequence of a type 4 hepatitis C virus variant, the predominant genotype in the Middle East. J Gen Virol. 1997;78: 1341-1347.
 
[10]  Amoroso P, Rapicetta M, Tosti M E, Mele A, Spada E, Buonocore S, Lettieri G, Pierri P, Chionne P, Ciccaglione A R, Sagliocca L. Correlation between virus genotype and chronicity rate in acute hepatitis C. J Hepatol. 1998; 28: 939ā€“944.
 
[11]  Zein N N, Rakela J, Krawitt E L, Reddy K R, Tominaga T, Persing D H. the Collaborative Study Group. Hepatitis C virus genotypes in the United States: epidemiology, pathogenicity, and response to interferon therapy. Ann Intern Med. 1996; 125: 634639.
 
[12]  Zein N N, Rakela J, Poterucha J J, Steers J L, Wiesner R H, Persing D H. Hepatitis C genotypes in liver transplant recipients: distribution and 1-year follow-up. Liver Transplant Surg. 1995; 1:354-357.