Resveratrol Prevents Motor Impairment Induced by Cassava Juice (Manihot esculenta Crantz) in Wistar Rats

Eduardo Rivadeneyra-Domínguez^1, , Aldo Alexis García-López¹, Isaac Zamora-Bello¹, Joel Jahaziel Díaz-Vallejo¹, Óscar Rosales-Sánchez¹ and Juan Francisco Rodríguez-Landa^{1, 2}

¹Facultad de Química Farmacéutica Biológica, Universidad Veracruzana, Xalapa 91000, México

²Laboratorio de Neurofarmacología, Instituto de Neuroetología, Universidad Veracruzana, Xalapa 91190, México

Cite this paper:
Eduardo Rivadeneyra-Domínguez, Aldo Alexis García-López, Isaac Zamora-Bello, Joel Jahaziel Díaz-Vallejo, Óscar Rosales-Sánchez and Juan Francisco Rodríguez-Landa. Resveratrol Prevents Motor Impairment Induced by Cassava Juice (Manihot esculenta Crantz) in Wistar Rats. Journal of Food and Nutrition Research. 2023; 11(3):168-175. doi: 10.12691/jfnr-11-3-1

Abstract

Cassava (Manihot esculenta Crantz) is a plant whose chronic consumption is associated with neurological diseases. On the other hand, resveratrol is a natural polyphenol that exerts antioxidant properties preventing the development of neurodegenerative diseases. However, it is unknown whether resveratrol can prevent motor incoordination induced by chronic consumption of cassava juice in rats. Fifty-six male Wistar rats were distributed in eight independent groups (n = 7 rats per group): Vehicle (water); Vehicle+Resveratrol; Cassava1+Vehicle; Cass2+Vehicle; Cass3+Vehicle; Cassava1+Resveratrol; Cassava2+Resveratrol; and Cassava3+Resveratrol. Treatments were orally co-administered every 24 hours for 28 consecutive days. One hour after the last administration, the effects were evaluated in the open-field, rota-rod, and swimming test. Cassava juice consumption increased motor activity in the open-field tests, induced spin behavior in the swimming test, and produced motor incoordination in the rota-rod test, which was prevented by the co-administration of resveratrol. The consumption of a dose of 10 mg/kg resveratrol for 28 days exerted a protective effect against motor impairment induced by cassava juice consumption in adult Wistar rats, probably associated with its antioxidant effects in the central nervous system.

Keywords:
antioxidant cassava juice neurologic disease motor impairment resveratrol

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