Eduardo Rivadeneyra-Domínguez^1,, Aldo Alexis García-López¹, Isaac Zamora-Bello¹, Joel Jahaziel Díaz-Vallejo¹, Óscar Rosales-Sánchez¹, Juan Francisco Rodríguez-Landa^{1, 2}

Cassava (Manihot esculenta Crantz) is a plant whose chronic consumption is associated with neurological diseases. On the other hand, resveratrol is a natural polyphenol that exerts antioxidant properties preventing the development of neurodegenerative diseases. However, it is unknown whether resveratrol can prevent motor incoordination induced by chronic consumption of cassava juice in rats. Fifty-six male Wistar rats were distributed in eight independent groups (n = 7 rats per group): Vehicle (water); Vehicle+Resveratrol; Cassava1+Vehicle; Cass2+Vehicle; Cass3+Vehicle; Cassava1+Resveratrol; Cassava2+Resveratrol; and Cassava3+Resveratrol. Treatments were orally co-administered every 24 hours for 28 consecutive days. One hour after the last administration, the effects were evaluated in the open-field, rota-rod, and swimming test. Cassava juice consumption increased motor activity in the open-field tests, induced spin behavior in the swimming test, and produced motor incoordination in the rota-rod test, which was prevented by the co-administration of resveratrol. The consumption of a dose of 10 mg/kg resveratrol for 28 days exerted a protective effect against motor impairment induced by cassava juice consumption in adult Wistar rats, probably associated with its antioxidant effects in the central nervous system.

antioxidant, cassava juice, neurologic disease, motor impairment, resveratrol