Stability Constant Determination of Substituted Thiopyrimidine Glucosides with Ni(II), Cu(II) and Zn(II)

R. R. Tayade^1, , R. K. Wanare², A. A. Sukhadeve³ and R. G. Mahakale⁴

¹Department of Chemistry, Institute of Science College, Nagpur (MS) India

²Jawaharlal Nehru Arts, Commerce and Science College, Wadi, Nagpur (MS) India

³Department of Chemistry, Institute of Forensic Science College, Nagpur (MS) India

⁴R. S. Bidkar College, Hanganghat, Wardha, (MS), India

Cite this paper:
R. R. Tayade, R. K. Wanare, A. A. Sukhadeve and R. G. Mahakale. Stability Constant Determination of Substituted Thiopyrimidine Glucosides with Ni(II), Cu(II) and Zn(II). World Journal of Analytical Chemistry. 2023; 8(1):1-5. doi: 10.12691/wjac-8-1-1

Abstract

Substituted thiopyrimidine glucosides are of great biological importance, but their metal-binding properties with biologically-relevant are not well investigated. Stability constants of the substituted thiopyrimidine glucosides with Ni(II), Cu(II) and Zn(II) metal were determined by . Substituted Thiopyrimidine Glucosides drugs are synthesized by reported method. The physic-chemical study of substituted thiopyrimidine carried out by pH-metric method by considering their interaction with Ni(II), Cu(II) and Zn(II) metal ions at 0.1 M ionic strength in 70 % DMF-water mixture by Bjerrum method as adopted by Calvin and Wilson. This study is useful to understand type of complex formation between transition metal ion and thiopyrimine glucosides drugs (L₁ and L₂). Present work deals with determination and comparison of stability constant.

Keywords:
substituted thiopyrimidines stability constants (pK) pH-metry

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