Geranyl Favonoid from Breadfruit Regulate Dyslipidemia in Hypercholesterolemic Rat

Hai Niu^{1, 2,} , Limei Ma¹, Ke Li^{1, 3}, Na Wang^{1, 4} and Wen Huang^1,

¹Laboratory of Ethnopharmacology, Institute for Nanobiomedical Technology and Membrane Biology, Regenerative Medicine Research Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China

²College of Mathematics, Sichuan University, Chengdu, China

³College of Light Industry, Textile and Food Engineering, Sichuan University, Chengdu, Sichuan, China

⁴Xinhua Hospital Attached to Dalian University, Department of Plastic Surgery, Dalian, Liaoning, China

Cite this paper:
Hai Niu, Limei Ma, Ke Li, Na Wang and Wen Huang. Geranyl Favonoid from Breadfruit Regulate Dyslipidemia in Hypercholesterolemic Rat. Journal of Food and Nutrition Research. 2015; 3(6):399-404. doi: 10.12691/jfnr-3-6-7

Abstract

Hpercholesterolemia is closely related to oxidative damages from high fat and cholesterol intakes. The geranyl flavonoid (GF) from Artocarpus altilis (Breadfruit) has potential antioxidant, anti-hyperlipidemia and anti-atherogenic properties. This work was to investigate the influence of GF on synthesis of cholesterol and lipogenesis in hypercholesterolemic rat fed with high-cholesterol diet. Treatment with GF significantly increased SOD, CAT, GPx and GR activities in organ tissues, as well as decreased TBARS activity compared to the untreated group. Total glutathione, NO and α-tocopherol contents in liver, kidney and adipose tissues in GF treated group were also higher than that in untreated group. In addition, the GF treatment increased ACAT and fatty acid synthase activities, and decreased HMG-CoA reductase activity. The results suggest that treatment of GF could inhibit the synthesis of cholesterol and the lipogenesis by regulating ACAT, HMG-CoA reductase and fatty acid synthase activities and improving the antioxidant defense status in hypercholesterolemic rat.

Keywords:
hypercholesterolemia geranyl flavonoid antioxidant enzyme

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