Journal of Food and Nutrition Research
ISSN (Print): 2333-1119 ISSN (Online): 2333-1240 Website: https://www.sciepub.com/journal/jfnr Editor-in-chief: Prabhat Kumar Mandal
Open Access
Journal Browser
Go
Journal of Food and Nutrition Research. 2023, 11(12), 759-771
DOI: 10.12691/jfnr-11-12-8
Open AccessArticle

Exploring the Application Prospects of Aboveground Parts of Codonopsis Pilosula in Agri-Food and Other Industries Based on Chemical Composition and Pharmacological Effects: A Review

Qianzhen Liu1, Huihui Zheng2, Ruhong Jiang3, Dong Wan4, and Huifeng Zhu5,

1Integrated Traditional Chinese and Western Clinical Medicine,Chongqing Medical University, Chongqing ,401331, China

2Chongqing Traditional Chinese Medicine Hospital , Chongqing, 400021,China

3Mental Health Center, University-Town Hospital of Chongqing Medical University, Chongqing,401331, China

4Department of Emergency & Critical Care Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

5College of Pharmaceutical Sciences and Traditional Chinese Medicine, Southwest University, Chongqing 400715, China

Pub. Date: December 18, 2023

Cite this paper:
Qianzhen Liu, Huihui Zheng, Ruhong Jiang, Dong Wan and Huifeng Zhu. Exploring the Application Prospects of Aboveground Parts of Codonopsis Pilosula in Agri-Food and Other Industries Based on Chemical Composition and Pharmacological Effects: A Review. Journal of Food and Nutrition Research. 2023; 11(12):759-771. doi: 10.12691/jfnr-11-12-8

Abstract

Due to the tradition of using the root as medicine and the lack of in-depth research, more than thousands of tonnes of above-ground parts of Codonopsis are still discarded every year, resulting in unimaginable waste of resources and environmental damage. In order to maximally utilize the nutrients in medicinal resources, we systematically reviewed the published literature on chemical composition, pharmacological experiments and exploitation, and summarized the amino acids, polysaccharides, saponins, terpenoids and flavonoids contained in the stems, leaves, flowers and seeds of Codonopsis pilosula into more than 130 kinds of 15 categories, and explained its anti-fatigue, anti-hepatic fibrosis, antioxidant, lipid regulating, immune enhancing, antibacterial and anticancer effects. It also summarises the new trends of its application in health food, edible mushroom cultivation, chemical medicine manufacturing and feed additives based on the amount of chemical enrichment from the perspectives of toxicity test, nutritional value and ecological benefits. The in-depth study will help to establish a more sustainable food system, improve the nutritional status of consumers, address the unmet needs in clinical, scientific research, and daily health care, and have a positive practical significance for the conservation, development and utilisation of medicinal plant resources.

Keywords:
Above ground part of Codonopsis pilosula Codonopsis pilosula pollen Codonopsis pilosula stem and leaves Chemical Composition Pharmacological effects Nutrient components

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References:

[1]  ChPC. Pharmacopoeia of the People's Republic of China 2020[M]. Beijing: China Medical Science Press, 2020.
 
[2]  Bi H, Zhang L, Chen Z, et al. An overview of research on germplasm resources of Radix Codonopsis and their utilization [J]. China Journal of Chinese Materia Medica, 2008, 33(5): 590-594.
 
[3]  Yang H, Chen Y, Guo F, et al. Resource investigation of wild Codonopsis pilosula in Tanchang county of Gansu [J]. China Journal of Chinese Materia Medica, 2016, 41(2): 186-191.
 
[4]  Lyu Y, Zhu R, Zhang J, et al. Research progress on chemical constituents and clinical intervention of Codonopsis pilosula under the concept of homology of medicine and food [J]. Chinese General Practice Nursing, 2023, 21(4): 457-461.
 
[5]  Li F,Chen Z, Ge J,et al. Intervention of Codonopsis Radix on ferroptosis and mitochondrial dynamics imbalance in mucosal cells of ulcerative colitis via PI3K/Akt [J].Chinese Traditional and Herbal Drugs, 2023, 54(12): 3865-3867.
 
[6]  Wang B, Li L, Yang X, et al. Research and Progress on the Extraction of the Main Effective Components of Radix et Rhizoma Ginseng [J].Chinese Journal of Animal Husbandry and Veterinary Medicine, 2023(8): 42-45.
 
[7]  Shi Q, Chen Z, Liu X, et al. Research progress on mechanism of action of Codonopsis Radix in treatment of gastric ulcer [J].Chinese Traditional and Herbal Drugs, 2023, 54(7): 2338-2348.
 
[8]  Wang Y, Wang Y, Cui F, et al. Amino acid composition and nutritional evaluation analysis and variety classification of three kinds of Codonopsis medicinal materials [J]. Lishizhen Medicine and Materia Medica Research, 2021, 32(10): 2421-2425.
 
[9]  Li L,Chen C, Hu X, et al. Research Progress on Chemical Constituents and Pharmacological Effects of Codonopsis pilosula [J]. Acta Chinese Medicine and Pharmacology, 2023, 51(3): 112-115.
 
[10]  Li F, Yang F. Research Progress on Extraction and Isolation,Chemical Compound and Pharmacological Effects of Polysaccharide from Dangshen( Codonopsis Radix) [J].Chinese Archives of Traditional Chinese Medicine, 2023, 41(4): 42-49.
 
[11]  Yang D, Chen Y, Guo F, et al. Study and application of above-ground parts of Codonopsis pilosula [J]. Chinese Traditional and Herbal Drugs, 2021, 52(13): 4055-4063.
 
[12]  Zheng H, Zhu H, Zhu R. Research progress on chemical constituents and pharmacological effects of aerial parts of Codonopsis pilosula [J]. Contemporary Medical Symposium, 2020, 20(4): 23-26.
 
[13]  Zeng X, Li J, Lyu X, et al. Untargeted Metabolomics Reveals Multiple Phytometabolites in the Agricultural.Waste Materials and Medicinal Materials of Codonopsis pilosula [J]. Front Plant Sci, 2021, 12: 814011.
 
[14]  Zhang X, Gao J, Cao L, et al. Survey of Codonopsis Germplasm Resourceand Production Status [J]. Chinese Archives Of Traditional Chinese Medicine, 2013, 31(03): 496-498.
 
[15]  Cai X, Sun X, Sun A, et al. Total Saponins in Stems and Leaves of Codonopsis pilosula:Extraction Process and Antioxidative Activity [J]. Chinese Agricultural Science Bulletin, 2018, 34(26): 146-151.
 
[16]  Hu Q, Jin M. Study on the Endangered Situation and Mechanism of Changium on Hangzhou Area [J]. Heilongjiang Agricultural Sciences, 2016(6): 101-105.
 
[17]  Li F, Li H, Ganghuan C, et al. Preliminary Investigation of Resources and Medicinal Use of Codonopsis canescens [J]. Chinese Journal of Experimental Traditional Medical Formulae, 2021, 27(1): 172-180.
 
[18]  Geng Y, Hu G, Sun W, et al. Resources and Development Strategy of Codonopsis lanceolata in Changbai Mountain [J]. Journal of Jilin Agricultural Sciences, 2010(11): 136-137.
 
[19]  Zhao Q, Chen J, Guo P, et al. Autotoxicity of Codonopsis pilosula [J]. Journal of Northwest Normal University (Natural Science), 2010, 46, 75-78+89.
 
[20]  Xie M. Study on Allelopathic Effect of Codonopsis Pilosula, Astragalus Hoantchy and Chemical Constituents in Aerial Part of Codonopsis Pilosula [D]. University of Chinese Academy of Sciences, 2018.
 
[21]  Bao X. Effect of Planting Density on Photosynthetic Characteristics and Yiel Quality of Codonopsis pilosula [J]. Agricultural Technology & Equipment, 2023(3): 17-19.
 
[22]  Chen Y, SU Y, He X, et al. The Efects of Artificial Cutting Method on the Seed Yield of GanSu BaiTiao DangShen [J]. Western Journal of Traditional Chinese Medicine, 2014, 27(2): 8-10.
 
[23]  Li Z. Analysis of the effect of different tip length on the yield of Codonopsis pilosula [J]. Information of Agricultural Science and Technology, 2015(6): 50-51.
 
[24]  Xiao S, Li F, Hu L, et al. Effects of Cutting Height and Time on Yield and Content of Codonopsis pilosula[J]. Shaanxi Journal of Agricultural Sciences, 2021, 67(4): 51-53.
 
[25]  Xiao S, Wang X, Li J, et al. Effect of Stem Cutting on Yield and Composition Content of Codonopsis pilosula [J]. Modern Agricultural Science and Technology, 2020 (1): 52, 57.
 
[26]  Hong Q, Liu Z, Zhao H, et al. Research of Application Forms and Processing Methods of Medicinal or Edible Codonopsis Plants Resources [J]. Modern Food, 2023, 29(3):6-15+28.
 
[27]  Jiang P, Yan Y, Zhao Z, et al. Analysis of nutritional components in aerial parts of Codonopsis pilosula [J]. Natural Product Research and Development, 1992, 4(3): 31-35.
 
[28]  Zheng H, Xu C, Zhu H, et al. Main Active Ingredients in Aboveground Part of Miaoyu Codonopsis Radix in Wushan [J]. China Pharmaceuticals, 2023, 32(3): 76-79.
 
[29]  Zhang Y, Chen J, Li X, et al. Accumulation and Distribution of Furanocoumarins in Rare Medicinal Plants Changium smyrnioides Wolff [J]. Natural Product Research and Development, 2012, 24(4): 510-513.
 
[30]  Zhang Y, Chen J, Xu J, et al. Tissue localization,Distribution and Fluorescence Relative Quantitative of Coumarins in Changium smyrnioides Wolff [J]. Lishizhen Medicine and Materia Medica Research, 2011, 22(3): 625-627.
 
[31]  Lin L, Zhuang M, Lei F, et al. GC/MS analysis of volatiles obtained by headspace solid-phase microextraction and simultaneous-distillation extraction from Rabdosia serra (MAXIM.) HARA leaf and stem.[J]. Food Chem, 2013, 136(2): 555-562.
 
[32]  Liu Z, Zhu G, Jin S. Studies on the Polysaccharides from the Pollen of Codonopsis Pilosula(Franch.)Nannf [J]. Chemical Journal of Chinese Universities, 1991, 12(12): 1600-1604.
 
[33]  Zhang Y. Structural characterization and in vitro antioxidant activities of polysaccharides from both roots and stems of two species of Radix Codonopsis.
 
[34]  Xie M, Li X, Liu J, et al. Isolation and Identification of Antiobesity Ingredients in Aerial Part of Codonopsis pilosula (Franch. ) Nannf [J]. Acta Botanica Boreali-Occidentalia Sinica, 2017, 37(10): 2082-2086.
 
[35]  Tang M, Liu Q, Liu Y, et al. Research Progress on Bioactivity and Product Development of Codonopsis pilosula Polysaccharide [J]. Science and Technology of Food Industry, 2022, 43(20): 464-470.
 
[36]  Yin L, Yin C, Lu C, et al. Active ingredients of Codonopsis pilosula and its application in livestock and poultry production [J].Feed Research, 2023, 46(11): 155-158.
 
[37]  Zhang J, Zhu R, Lu Y, et al. Codonopsis and its active ingredients in the immunotherapy of diseases [J].Shanxi Medical Journal, 2023, 52(14): 1069-1074.
 
[38]  Fu J, Zhao H, Wang Y. Effect of Codonopsis pilosula polysaccharide on learning and memory ability of aging model rats and its related mechanism [J].Chinese Journal of Gerontology, 2023, 43(11): 2727-2730.
 
[39]  Xing X, Zhao H, Li L, et al. Therapeutic Effectiveness of Codonopsis Pilosula Polysaccharide on Mice with Anemia Induced by Cyclophosphamide [J]. Clinical Misdiagnosis and Mistherapy. 2022, 35(1): 99-102.
 
[40]  Zeng X, Li J, Lyu X, et al. Utilization of functional agro-waste residues for oyster mushroom production: Nutritions and active ingredients in healthcare [J]. Front Plant Sci, 2022, 13: 1085022.
 
[41]  Yang X, Zhu H, Wan D, et al. Comparative Analysis of Amino Acid Composition and Nutritional Value of Roots of Codonopsis pilosula from Wushan and Other Growing Regions in China [J].Food Science, 2014, 35(15): 251-257.
 
[42]  Shu J, Wang Y, Wang H, et al. Research Progress on quality control of pharmacodynamic active components of Codonopsis pilosula [J]. Capital Food Medicine, 2022, 13(29): 12-14.
 
[43]  Piao K, Han C, Shen Y, et al. Study on the nutritive compositions of Codonopsis lanceolata [J]. Chinese Wild Plant Resources, 1998, 17(4): 28-30.
 
[44]  Yan Y. Basic Research on Aboveground Parts of Codonopsis pilosula ( Bulletin )[J]. 2002, 14(1): 30.
 
[45]  Liu J, Bao Y, Song J, et al. Codonopsis pilosula(Franch)Nannf total alkaloids potentiate neurite outgrowth induced by nerve growth factor in PC12 cells [J]. Acta Pharmacologica Sinica, 2003, 24(9): 913-917.
 
[46]  Yan Y, Jiang P, Shen L. Study on volatile oil components in stems and leaves of Codonopsis pilosula [J]. 1993, 24(7): 384-385.
 
[47]  Fan Q, Zhou X, A P, et al. Study on chemical constituents of volatile oil from aerial parts of Codonopsis tangshen [J]. Shaanxi Journal of Agricultural Sciences, 2009(5): 56-57.
 
[48]  Lu F, Fu Y, Ni S, et al. Recent Advances in the Utilization of Lignin and Lignin-based Products in Pharmaceutic Preparation [J]. Journal of Cellulose Science and Technology, 2022, 30(3): 36-44.
 
[49]  Bhardwaja P, Naryala A, Thakura M S, et al. Comparative antioxidant, antibacterial, and GC-MS analysis of methanol extract's fractions and isolation of luteolin from leaves of trans-Himalayan Codonopsis clematidea [J]. Industrial Crops & Products, 2020(144): 112046.
 
[50]  Yang D, Chen Y, Guo F, et al. Comparative analysis of chemical composition,antioxidant and antimicrobial activities of leaves, leaf tea and root from Codonopsis pilosula [J]. Industrial Crops & Products, 2019(142): 111844.
 
[51]  Li K, Chen W, Zhou X, et al. Efects of Codonopsis PUosula Polysaccharides on the Production Performance,Imm une Function Routine Blood Indexes and IntestinalM icroflora of Black-bone Chicken [J]. Sichuan Animal & Veterinary Sciences, 2017, 44(10): 32-34.
 
[52]  Fu Y P, Feng B, Zhu Z K, et al. The Polysaccharides from Codonopsis pilosula Modulates the Immunity and Intestinal Microbiota of Cyclophosphamide-Treated Immunosuppressed Mice [J]. Molecules, 2018, 23(7).
 
[53]  Li Z, Jiang J, Qing C, et al. Preventive and Cnrative effects of Bee Pollen of Codonopsis Pilosula Nannf on Chronis hepatic injury by CCI4 [J]. Journal of Kunming Medical University, 1989, 10(4): 17-21.
 
[54]  Xiao J, Liu H, Han D, et al. Protective effect of Codonopsis pilosula pollen on liver injury from ultrastructure [J]. China Journal of Chinese Materia Medica, 1989(3): 42-44, 64.
 
[55]  Xiao J, Qian W, Han D, et al. Therapeutic Effects of Dangshen Pollen on Experimental Hepatic Fibrosis at Ultrastructural Level [J]. Journal of Kunming Medical University, 1988(04): 7-9.
 
[56]  Wu Z. The development of Codonopsis pilosula stem-leaf astragalus powder and studies on its immunological enhancement [D]. Nanjing Agricultural University, 2019.
 
[57]  Ma Y, Zhang L, Su X, et al. Study on oral administration of six herbal tonics on the antibody responses induced byf oot-and-mouth disease vaccine [J]. Chinese Journal of Preventive Veterinary Medicine, 2015, 37(1): 49-52.
 
[58]  Ren H, Zhang Z, Pang H, et al. Research and utilization of Chinese herbal medicine feed additive nutrients [J]. Journal of Animal Science and Veterinary Medicine, 2015, 34(3): 39-41.
 
[59]  Ma Z. Effects of Codonopsis stems and leaves on growth performance of broilers [J]. Animal Husbandry & Veterinary Medicine, 2015, 47(1): 147.
 
[60]  Li C, Hou W, Wang G, et al. Immunopharmacologic Effect of Codonopsis Pilosula Pollen [J]. Journal of Kunming Medical University, 1989(1): 38-41.
 
[61]  Li C, Zhu X, Li Z, et al. Observation on immune function, hemogram and plasma protein electrophoresis of Codonopsis pilosula pollen in normal mice [J]. Apiculture of China, 1987(04): 16-18.
 
[62]  He R, Ma R, Jin Z, et al. Proteomics and Metabolomics Unveil Codonopsis pilosula (Franch.) Nannf. Ameliorates Gastric Precancerous Lesions via Regulating Energy Metabolism [J]. Front Pharmacol, 2022, 13: 933096.
 
[63]  Bailly C. Anticancer Properties of Lobetyolin, an Essential Component of Radix Codonopsis (Dangshen) [J]. Nat Prod Bioprospect, 2021, 11(2): 143-153.
 
[64]  Yu Y, Ding S, Xu X, et al. Integrating Network Pharmacology and Bioinformatics to Explore the Effects of Dangshen (Codonopsis pilosula) Against Hepatocellular Carcinoma: Validation Based on the Active Compound Luteolin [J]. Drug Des Devel Ther, 2023, 17: 659-673.
 
[65]  Wan L, Zhang Q, Luo H, et al. Codonopsis pilosula polysaccharide attenuates Abeta toxicity and cognitive defects in APP/PS1 mice [J]. Aging (Albany NY), 2020, 12(13): 13422-13436.
 
[66]  Chen S, Liao Y, Zhuo G, et al. Non-specific activation of mouse peritoneal macrophages by Codonopsis pilosula pollen polysaccharide [J]. Chinese Journal of Immunology, 1991(03): 187.
 
[67]  Lu Y, Tian K, Yang R. Observation on the protective effect of Codonopsis pollen on bone marrow hematopoietic function injury [J]. Journal of Bee, 1996(9): 6-8.
 
[68]  Tian K, lu Y, Yang R. Effect of Codonopsis pilosula pollen on hematopoietic system in mice [J]. Journal of Bee, 1992(3): 3.
 
[69]  Yin D. Codonopsis pollen for the treatment of aplastic anemia [J]. Journal of Bee, 1989(03): 9-10.
 
[70]  Cai D, Zhang X, Zhou Q, et al. Preliminary observation on the effect of Lu Dangshen pollen in the treatment of 26 cases of hematopoietic dysfunction caused by radiotherapy and chemotherapy [J]. Journal of Traditional Chinese Medicine, 1987(11): 25-26.
 
[71]  Shu Y, Zhang Z, Liang H. Preliminary study on the effect of different components of Codonopsis pollen on smooth muscle [J]. Sichuan Journal of Physiological Sciences, 1988(4): 45-46.
 
[72]  Shu Y, Liang H, Zhang Z. Effects of different components of Codonopsis pilosula and poppy pollen on biliary tract and biliary sphincter [J]. Sichuan Journal of Physiological Sciences, 1988(04): 44.
 
[73]  Shu Y, Liang H, Zhang Z. Anti fatigue,high-temperature and low-temperature effects of Codonopsis pilosula, poppy pollen and their extracts [J]. Sichuan Journal of Physiological Sciences, 1988, 4: 44-45.
 
[74]  Ding X, Li X. Analysis of Fatty Acid in Codonopsis pilosula Pollen by GC-MS [J]. Acta Agriculturae Jiangxi, 2007, 19(5).
 
[75]  Xiong F. Codonopsis pilosula stems and leaves are good feed [J]. Modern Animal Husbandry Science & Technology, 2006(3): 19.
 
[76]  Hu J. Experiment on feeding fattening pigs with Codonopsis pilosula and its stems and leaves [J]. Feed Research, 1996(12): 20.
 
[77]  Dong Z. Effect of Codonopsis stems and leaves on pig production performance [J]. Animal Husbandry and Veterinary Medicine, 2014, 46(12): 139.
 
[78]  Guo F, Liu D, Zhang L, et al. Effects of Maifan Stone, Seabuckthorn Leaves and Codonopsis Stem Leaves on Protein Metabolism in Chicken Diet [J]. Journal of Traditional Chinese Veterinary Medicine, 1994(4): 13-14.
 
[79]  Guo F, Liu D, Zhang L, et al. Effects of Seabuckthorn leaves and Codonopsis stems and leaves on egg quality [J]. Gansu Animal Husbandry and Veterinary, 1992(3): 16-17.
 
[80]  He G, Wang J, Guo F, et al. Effect of Codonopsis stems and leaves on production performance of laying hens [J]. Journal of Traditional Chinese Veterinary Medicine, 1989(3): 9-11.
 
[81]  Tian K, Guo C. Accumulation toxicity test of Codonopsis pollen [J]. Journal of Bee, 1993(01): 4-5.
 
[82]  He G, Wang J, Guo F, et al. Acute and chronic toxicity test of stems and leaves of Codonopsis pilosula [J]. Chinese Journal of Veterinary Science And Technology, 1988(01): 53-54.
 
[83]  Chen H, Yang D, Guo F, et al. A method for processing high-aroma Codonopsis pilosula leaf green tea by microwave technology.
 
[84]  Zhang X, Zhang G, He X, et al. Codonopsis stems and leaves health drinks and Codonopsis stems and leaves tea production methods: 20170315.
 
[85]  Wu Y, Wu Z, Li Y. Codonopsis leaf tea and its production process: 2016.02.10.
 
[86]  Cao L, Du C, Zhai X, et al. Codonopsis pilosula Polysaccharide Improved Spleen Deficiency in Mice by Modulating Gut Microbiota and Energy Related Metabolisms [J]. Front Pharmacol, 2022, 13: 862763.
 
[87]  Li J, Dong L, Liu Y, et al. Stimulation of Codonopsis pilosula Polysaccharide on Bifidobacterium of Human Gut Bacteria In Vitro [J]. Evid Based Complement Alternat Med, 2021, 2021: 9524913.
 
[88]  Cheng M, Pi W, Lu T, et al. Determination of lobetyolin and polysaccharide content in the aboveground part of Codonopsis pilosula and analysis of influencing factors [J]. Journal of Chinese Medicinal Materials, 2020, 43(05): 1092-1098.
 
[89]  Wang M. Effects of different hormone ratios on polysaccharide content in callus induced growth of Codonopsis pilosula [D]. Lanzhou University, 2004.
 
[90]  Shang E. Synthesis and Application of Coumarin and Its Derivatives [J]. Modern Agrochemicals, 2011, 5(10): 1-3.
 
[91]  Chai Y. Cultivation technology of Coprinus comatus by stems and leaves of Astragalus membranaceus and Glycyrrhiza uralensis[ J]. Gansu Agricultural Science and Technology, 2011(10): 60-61.
 
[92]  Guo S, Zeng X, Chen J. An edible fungus cultivation substrate containing Codonopsis stems and leaves and its use: 2021.05.07.
 
[93]  Zeng X, Chen J, Guo S. The Use of Stems and Leaves of Codonopsis pilosula to Cultivate Pleurotus ostreatus [J]. Acta Edulis Fungi, 2020, 27(4): 59-64.
 
[94]  Li J, Chen X, Chen J, et al. Safety Evaluation of Pleurotus ostreatus and Flammulina velutipes Cultivated by the Stems and Leaves of Astragalus membranaceus and Codonopsis pilosula [J]. Edible Fungi of China, 2022, 41(01): 58-61.
 
[95]  Guo Y, Chen H, Liu M, et al. A fermentation extract of Codonopsis pilosula stems and leaves and its preparation method and application: 2015.10.07.
 
[96]  Song S, Fan S. Studies on Radix Codonopsis Resource [J].Science Popularization in University. 2022(4): 62-65.