A Novel Diagnostic and Predictor of Clear Cell Renal Cell Carcinoma: VWA3B

Xue Cao¹, Yu Li¹, MingBo Luo¹ and Jianping Li^1,

¹The Third Affiliated Hospital of Zunyi Medical University, The First People’s Hospital of Zunyi, Zunyi, Guizhou, 563000, China.

Cite this paper:
Xue Cao, Yu Li, MingBo Luo and Jianping Li. A Novel Diagnostic and Predictor of Clear Cell Renal Cell Carcinoma: VWA3B. Journal of Food and Nutrition Research. 2023; 11(10):630-637. doi: 10.12691/jfnr-11-10-4

Abstract

Clear renal cell carcinoma (ccRCC) is the most common pathological subtype of renal cell carcinoma, accounting for about 70% of all renal cell carcinomas. This article aims to discuss the relationship between VWA3B and the prognostic risk, clinical characteristics, overall survival of patients with clear renal cell carcinoma and the relationship between related pathways. Using The Cancer Genome Atlas (TCGA) database, we evaluated the association of VWA3B with CCRCC. The results showed that the expression of VWA3B in renal cell carcinoma tissues was lower than that in normal tissues (***, P < 0.001). The low expression of VWA3B had clinical significance, such as clinical stage (P=0.0051) and TNM stage (T:P < 0.001; N: P = 0.03; M: P =0.01). Through ROC curve analysis, VWA3B was not only closely related to the favorable prognosis of RCC (hazard ratio [HR] =1.373, 95% CI, 1.017-1.852, P = 0.037), but also had a high diagnostic value (AUC = 0.789). Correlation between VWA3B expression and immune cell infiltration in clear renal cancer cells. Abbreviation: ccRCC = Clear renal cell carcinoma, HGNC = HUGO Gene Nomenclature Committee, IBD = identical by descent, GSEA = Gene set enrichment analysis, OS = overall survival, ROC = receiver operating characteristic, TCGA = The Cancer Genome Atlas.

Keywords:
TCGA ccRCC VWA3B

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