Journal of Food and Nutrition Research
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Journal of Food and Nutrition Research. 2019, 7(10), 751-758
DOI: 10.12691/jfnr-7-10-9
Open AccessArticle

Diet Based on Food from the Colombian Andean Region Decreases C-reactive Protein, IL6, and Leptin in Women with Obesity

Elcy Yaned1, Astudillo -Muñoz1, 2, , Clara Helena González-Correa1, Diana María1, Muñoz -Pérez1, 2, Erika Martinez-Lopez3, Daniel Camilo Aguirre-Acevedo4 and María Elena Alvarez Lopez5

1Department of Basic Sciences for Health, Research Group on nutrition, Metabolism and Food Security, Universidad de Caldas, Manizales, Colombia

2Department of Health Sciences, Care Management Group, Universidad Libre Pereira, Colombia

3Department of Molecular Biology and Genomic, Health Sciences University Center, University of Guadalajara, Guadalajara, Jalisco, Mexico

4Academic Group of Clinical Epidemiology, Institute of Medical Research, Faculty of Medicine, Universidad de Antioquia, Medellín, Colombia

5Department of Basic Sciences for Health, Research Group on Regenerative Therapy, Universidad de Caldas, Manizales, Colombia

Pub. Date: October 27, 2019

Cite this paper:
Elcy Yaned, Astudillo -Muñoz, Clara Helena González-Correa, Diana María, Muñoz -Pérez, Erika Martinez-Lopez, Daniel Camilo Aguirre-Acevedo and María Elena Alvarez Lopez. Diet Based on Food from the Colombian Andean Region Decreases C-reactive Protein, IL6, and Leptin in Women with Obesity. Journal of Food and Nutrition Research. 2019; 7(10):751-758. doi: 10.12691/jfnr-7-10-9


People with obesity develop low-grade chronic inflammation, which is characterized by a high serum concentration of inflammatory markers (CRP, IL-6, TNF-α, and leptin), which predisposes the development of chronic diseases. These markers can be modulated by a diet; therefore, a research project was developed to determine the effect of a diet based on foods available in the Colombian Andean Region, containing anti-inflammatory properties in obese women. A controlled study was conducted with 30 women. For eight weeks the experimental group received a diet based on food rich in fiber, polyunsaturated fatty acids, vitamins and polyphenols. The experimental group reduced the serum concentrations of CRP (p = 0.005), IL-6 (p = 0.013) and leptin (p = 0.004), in comparison with the control group. Therefore, the findings suggest that a diet based on foods available in the Colombian Andean Region with anti-inflammatory nutrients reduces CRP, IL-6 and leptin in obese women.

diet inflammation biomarkers obesity colombia

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