Journal of Food and Nutrition Research
ISSN (Print): 2333-1119 ISSN (Online): 2333-1240 Website: https://www.sciepub.com/journal/jfnr Editor-in-chief: Prabhat Kumar Mandal
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Journal of Food and Nutrition Research. 2019, 7(9), 652-655
DOI: 10.12691/jfnr-7-9-5
Open AccessArticle

Anti-aging and Anti-oxidation – Salmon Sperm as a Substitute for Nucleotide Sources

Chen-Meng Kuan1, , Kai-Wen Kan2, Jia-Haur Chen2, Young-Hao Lin3 and Yung-Hsiang Lin1

1Research & Design Center, TCI CO., Ltd., Taipei, Taiwan

2Research & Design Center, TCI Gene Inc., Taipei, Taiwan

3Global Business Center, TCI CO., Ltd., Taipei, Taiwan

Pub. Date: September 20, 2019

Cite this paper:
Chen-Meng Kuan, Kai-Wen Kan, Jia-Haur Chen, Young-Hao Lin and Yung-Hsiang Lin. Anti-aging and Anti-oxidation – Salmon Sperm as a Substitute for Nucleotide Sources. Journal of Food and Nutrition Research. 2019; 7(9):652-655. doi: 10.12691/jfnr-7-9-5

Abstract

This research unveils the possibility of a salmon sperm formula, called DNA drink, for anti-aging and anti-oxidation. The applications of salmon sperm have been rarely reported in scientific investigations if compared with salmon roe, but salmon sperm also contains copious nucleotides. Our experiments confirmed that the DNA drink could enhance the anti-oxidant ability and improve the expression levels of aging-related genes (CCT2, CCT6A, Atg1, Atg8, and SIRT1 genes) in peripheral blood mononuclear cells (PBMCs). These results suggest the potential of salmon sperm for boosting cell vitality and protecting cells from oxidative damage.

Keywords:
salmon sperm anti-oxidant anti-aging nucleotide supplement cell viability

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References:

[1]  Kinney, M., Seider, J., Beaty, A.F., Coughlin, K., Dyal, M., Clewley, D., The impact of therapeutic alliance in physical therapy for chronic musculoskeletal pain: a systematic review of the literature. Physiotherapy Theory and Practice, 2018. 28: p. 1-13.
 
[2]  Liguori, I., et al., Oxidative stress, aging, and diseases. Clinical Interventions in Aging, 2018. 13: p. 757-772.
 
[3]  Wu, B.-H., Wang, W.-C. and Kuo, H.-Y., Effect of multi-berries drink on endogenous antioxidant activity in subjects who are regular smokers or drinkers. Journal of Food and Nutrition Research, 2016. 4: p. 289-295.
 
[4]  Beckman, K.B. and Ames, B.N., The free radical theory of aging matures. Physiological Review, 1998. 78: p. 547-581.
 
[5]  Davalli, P., Mitic, T., Caporali, A., Lauriola, A. and D'Arca, D., ROS, cell senescence, and novel molecular mechanisms in aging and age-related diseases. Oxidative Medicine and Cellular Longevity, 2016. 2016: p. 3565127.
 
[6]  Das, T.K., Wati, M.R., Fatima-Shad, K., Oxidative stress gated by Fenton and Haber Weiss reactions and its association with Alzheimer’s disease. Archives of Neuroscience, 2015. 2: p. e20078.
 
[7]  Panth, N., Paudel, K.R., Parajuli, K., Reactive oxygen species: a jey hallmark of cardiovascular disease. Advances in Medicine, 2016. 2016: p. 9152732.
 
[8]  Gil Del Valle, L., Oxidative stress in aging: theoretical outcomes and clinical evidences in humans. Biomedicine & Aging Pathology, 2011. 1: p. 1-7.
 
[9]  Kageyama, H. and Waditee-Sirisattha, R., Antioxidative, anti-inflammatory, and anti-aging properties of mycosporine-like amino acids: molecular and cellular mechanisms in the protection of skin-aging. Marine Drugs, 2019. 17: p. 222.
 
[10]  Fakhruddin, S., Alanazi, W. and Jackson, K.E., Diabetes-induced reactive oxygen species: mechanism of their generation and role in renal injury. Journal of Diabetes Research, 2017. 2017: p. 8379327.
 
[11]  El-Kenawi, A. and Ruffell, B., Inflammation, ROS, and mutagenesis. Cancer Cell, 2017. 32, p. 727-729.
 
[12]  Kim, G.H., Kim, J.E., Rhie, S.J., Yoon, S., The role of oxidative stress in neurodegenerative diseases. Experimental Neurobiology, 2015. 24: p. 325-340.
 
[13]  Adams, L., Franco, M.C., Estevez, A.G., Reactive nitrogen species in cellular signaling. Experimental Biology and Medicine, 2015. 240: p. 711-717.
 
[14]  Tu, W., Wang, H., Li, S., Liu, Q., Sha, H., The anti-inflammatory and anti-oxidant mechanisms of the Keap1/Nrf2/ARE signaling pathway in chronic diseases. Aging and Disease, 2019. 10: 637-651.
 
[15]  Kansanen, E., Kuosmanen, S.M., Leinonen, H., Levonen, A.L., The Keap1-Nrf2 pathway: mechanisms of activation and dysregulation in cancer. Redox Biology, 2013. 1: p. 45-49.
 
[16]  Xu, M., Liang, R., Li, Y., Wang, J., Anti-fatigue effects of dietary nucleotides in mice. Food & Nutrition Research, 2017. 61: p. 1334485.
 
[17]  Xu, M., Zhao, M., Yang, R., Zhang, Z., Li, Y., Wang, J., Effect of dietary nucleotides on immune function in Balb/C mice. International Immunopharmacology, 2013. 17: p. 50-56.
 
[18]  Salobir, J., Rezar, V., Pajk, T., Levart, A., Effect of nucleotide supplementation on lymphocyte DNA damage induced by dietary oxidative stress in pigs. Animal Science, 2005. 81: p. 135-140.
 
[19]  Shiau, S.Y., Gabaudan, J., Lin, Y.H., Dietary nucleotide supplementation enhances immune responses and survival to Streptococcus iniae in hybrid tilapia fed diet containing low fish meal. Aquaculture Reports, 2015. 2: p. 77-81.
 
[20]  Xu, M., et al., Dietary nucleotides extend the life span in Sprague-Dawley rats. The Journal of Nutrition, Health & Aging, 2013. 17: p. 223-229.
 
[21]  Marotta, F., et al., Beneficial modulation from a high-purity caviar-derived homogenate on chronological skin aging. Rejuvenation Research, 2012. 15: p. 174-177.
 
[22]  Yoshino, A., Polouliakh, N., Meguro, A., Takeuchi, M., Kawagoe, T. and Mizuki, N., Chum salmon egg extracts induce upregulation of collagen type I and exert antioxidative effects on human dermal fibroblast cultures. Clinical Interventions in Aging, 2016. 11: p. 1159-1168.
 
[23]  Zhang, S. and Duan, E., Fighting against skin aging: the way from Bench to Bedside. Cell Transplantation, 2018. 27: p. 729-738.
 
[24]  Noormohammadi, A., Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan. Nature Communication, 2016. 7: p. 13649.
 
[25]  Lee, Y.-K., Lee, J.-A., Role of the mammalian ATG8/LC3 family in autophagy: differential and compensatory roles in the spatiotemporal regulation of autophagy. BMB Reports, 2016. 49: p. 424-430.
 
[26]  Salminen, A., Kaarniranta, K., Kauppinen, A., Crosstalk between oxidative stress and SIRT1: impact on the aging process. International Journal of Molecular Sciences, 2013. 14: p. 3834-3859.