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ISSN (Print): 2333-1119 ISSN (Online): 2333-1240 Website: https://www.sciepub.com/journal/jfnr Editor-in-chief: Prabhat Kumar Mandal
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Journal of Food and Nutrition Research. 2019, 7(11), 794-800
DOI: 10.12691/jfnr-7-11-6
Open AccessArticle

Role of Thyme Extract against Some Biochemical Alterations Induced by Propylthiouracil in Male Rats

Osman H.F.1, El-Mahdey A.A.1 and El-Sherbiny E.M.1,

1Radioisotopes Department, Nuclear Research Center, Atomic Energy Authority, Egypt

Pub. Date: November 23, 2019
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Cite this paper:
Osman H.F., El-Mahdey A.A. and El-Sherbiny E.M.. Role of Thyme Extract against Some Biochemical Alterations Induced by Propylthiouracil in Male Rats. Journal of Food and Nutrition Research. 2019; 7(11):794-800. doi: 10.12691/jfnr-7-11-6

Abstract

The present investigation was designed to investigate the curative and protective effect of thyme as a natural product on thyroid and liver status in hypothyroid rats induced by propylthiouracil (PTU). The rats were classified into 4 groups; group I: control, group II, was intraperitoneally injected with 10 mg PTU/kg, for 21 days, group III was i.p. injected with 10 mg PTU/kg, for 21 days followed by 5% thyme for four weeks, and group IV was i.p. injected with 10 mg PTU/kg, for 21 days followed by 10% thyme for four weeks. Serum total cholesterol, HDL, LDL, triglycerides, AST, ALT, alkaline phosphatase, total protein, albumin, urea, creatinine, Na+, K+, GSH, GSH-px, SOD, MDA, TNF-∝, serum triiodothyronine (T3) and thyroxine (T4), were evaluated. Propylthiouracil injection resulted in a significant increase in total cholesterol, LDL, triglycerides, AST, ALT, ALP, urea and creatinine, MDA, and TNF-∝, whereas HDL, total protein, albumin, Na+, K+, GSH, GSH-px, SOD, T3 and T4 decreased significantly compared to control. The high dose of thyme extract (10%) ameliorated most of the harmful effect of PTU, this may be due to its contents of flavonoids, thymol, phenols and luteolin.

Keywords:
Propylthiouracil Thymus vulgaris L. liver functions lipid peroxides kidney functions thyroid functions rats

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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