Hypotentive and Antihypertentive Effect of Leaves Aqueous Extract of Saccharum officinarum(Poaceae) on Rabbits

Irié Bi Jean Sévérin^1, , Kahou Bi Gohi Parfait², Goli Adjo Naomie Franceline¹, Néné Bi Sémi Anthelme¹ and Abo Kouakou Jean-Claude¹

¹Biology and Health Laboratory, Physiology and Pharmacology specialist, Felix HOUPHOUET-BOIGNY University, 22 BP 582 Abidjan 22, Ivory Coast

²Agrovalorization Laboratory, Physiology and Pharmacology specialist, Jean LOROUGNON GUEDE University, BP 150 Daloa, Ivory Coast

Cite this paper:
Irié Bi Jean Sévérin, Kahou Bi Gohi Parfait, Goli Adjo Naomie Franceline, Néné Bi Sémi Anthelme and Abo Kouakou Jean-Claude. Hypotentive and Antihypertentive Effect of Leaves Aqueous Extract of Saccharum officinarum(Poaceae) on Rabbits. American Journal of Medical Sciences and Medicine. 2025; 13(3):34-39. doi: 10.12691/ajmsm-13-3-2

Abstract

Saccharum officinarum L. (Poaceae) is a plant used in traditional medicine to treat high blood pressure. In order to provide a scientific basis, this study was undertaken. Thus, we carried out a study of the antioxidant activity and pharmacological tests on the leaves aqueous extract of Saccharum officinarum L. (Poaceae). The DPPH test showed that Esol contains antioxidants with an IC₅₀ of 0.5211 mg/mL. Pharmacological effects showed that Esol induced dose-dependent hypotension at doses ranging from 1 mg/kg B.W. to 20 mg/kg B.W., with a 50% Effective Dose of 5.17 mg/kg B.W. Interactions between the extract and pharmacological substances revealed that atropine had no significant effect (p > 0.05) on Esol-induced hypotension. The extract significantly reduced and cancelled (p < 0.01; p < 0.001) adrenaline and Isoprenalin-induced hypertension by 88.7 ± 6% and 81.88 ± 4.5% respectively, followed by hypotension of 46.9 ± 3.1% and 43.3±2.6%. These results justify the use of Saccharum officinarum in the treatment in cardiovascular disorders.

Keywords:
Saccharum officinarum antioxidant hypotensive antihypertensive

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