Irié Bi Jean Sévérin^1,, Kahou Bi Gohi Parfait², Goli Adjo Naomie Franceline¹, Néné Bi Sémi Anthelme¹, Abo Kouakou Jean-Claude¹

Saccharum officinarum L. (Poaceae) is a plant used in traditional medicine to treat high blood pressure. In order to provide a scientific basis, this study was undertaken. Thus, we carried out a study of the antioxidant activity and pharmacological tests on the leaves aqueous extract of Saccharum officinarum L. (Poaceae). The DPPH test showed that Esol contains antioxidants with an IC₅₀ of 0.5211 mg/mL. Pharmacological effects showed that Esol induced dose-dependent hypotension at doses ranging from 1 mg/kg B.W. to 20 mg/kg B.W., with a 50% Effective Dose of 5.17 mg/kg B.W. Interactions between the extract and pharmacological substances revealed that atropine had no significant effect (p > 0.05) on Esol-induced hypotension. The extract significantly reduced and cancelled (p < 0.01; p < 0.001) adrenaline and Isoprenalin-induced hypertension by 88.7 ± 6% and 81.88 ± 4.5% respectively, followed by hypotension of 46.9 ± 3.1% and 43.3±2.6%. These results justify the use of Saccharum officinarum in the treatment in cardiovascular disorders.

Saccharum officinarum, antioxidant, hypotensive, antihypertensive