Identification and Quantitative Analysis of 2-Phenylethanol as Major Impurity in Bromadol by HPLC

Zhi Li^1, , Ting Huang², Jia-Hao Guo¹ and Jing-Xiang Zhuang¹

¹Department of Chemistry, School of Science, Beijing Jiaotong University, Beijing, China

²Division of Chemical Metrology and Analytical Science, National Institute of Metrology, Beijing, China

Cite this paper:
Zhi Li, Ting Huang, Jia-Hao Guo and Jing-Xiang Zhuang. Identification and Quantitative Analysis of 2-Phenylethanol as Major Impurity in Bromadol by HPLC. World Journal of Analytical Chemistry. 2014; 2(1):6-9. doi: 10.12691/wjac-2-1-2

Abstract

Bromadol can serve as a powerful and versatile agent in medicinal chemistry. In this paper, 2-phenylethanol was first identified as a main impurity in commercial Bromadol sample by HPLC. HPLC quantitative analysis method for impurity 2-phenylethanol in Bromadol has also been established for the first time. By our new HPLC analysis method, the impurity 2-phenylethanol was found to be 9.6% by weight. The identified main impurity 2-phenylethanol can be successfully removed by heating under vacuum, which gave an easy way to purify Bromadol for mass production.

Keywords:
HPLC Bromadol 2-phenylethanol

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