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Liu, Z. H.; Jin, W. Q.; Dai, Q. Y.; Chen, X. J.; Zhang, H. P.; Chi, Z. Q. Life Sci, 2003, 73, 233-241.

has been cited by the following article:

Article

Identification and Quantitative Analysis of 2-Phenylethanol as Major Impurity in Bromadol by HPLC

1Department of Chemistry, School of Science, Beijing Jiaotong University, Beijing, China

2Division of Chemical Metrology and Analytical Science, National Institute of Metrology, Beijing, China


World Journal of Analytical Chemistry. 2014, Vol. 2 No. 1, 6-9
DOI: 10.12691/wjac-2-1-2
Copyright © 2014 Science and Education Publishing

Cite this paper:
Zhi Li, Ting Huang, Jia-Hao Guo, Jing-Xiang Zhuang. Identification and Quantitative Analysis of 2-Phenylethanol as Major Impurity in Bromadol by HPLC. World Journal of Analytical Chemistry. 2014; 2(1):6-9. doi: 10.12691/wjac-2-1-2.

Correspondence to: Zhi  Li, Department of Chemistry, School of Science, Beijing Jiaotong University, Beijing, China. Email: zhili@bjtu.edu.cn

Abstract

Bromadol can serve as a powerful and versatile agent in medicinal chemistry. In this paper, 2-phenylethanol was first identified as a main impurity in commercial Bromadol sample by HPLC. HPLC quantitative analysis method for impurity 2-phenylethanol in Bromadol has also been established for the first time. By our new HPLC analysis method, the impurity 2-phenylethanol was found to be 9.6% by weight. The identified main impurity 2-phenylethanol can be successfully removed by heating under vacuum, which gave an easy way to purify Bromadol for mass production.

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