Assessment of Altered Plasma Lipid Pattern in Plasmodium Falciparum Malaria Infected and Non Infected Individuals

ESAN AYODELE JACOB^1,

¹Department of Haematology and Blood Transfusion Science, Federal Medical Centre, P.M.B 201 Ido-Ekiti, Nigeria

Cite this paper:
ESAN AYODELE JACOB. Assessment of Altered Plasma Lipid Pattern in Plasmodium Falciparum Malaria Infected and Non Infected Individuals. International Journal of Hematological Disorders. 2014; 1(1):27-30. doi: 10.12691/ijhd-1-1-5

Abstract

This study aimed to assess blood lipid profile status in pre, post anti-malaria drug treatment in Plasmodium falciparum malaria parasite infected patients and control individuals. Two hundred and two blood samples were collected pre-treatment and post anti-malaria drug treatment. Lipid profile was estimated using CHOD-PAP method; Thick blood film was made. Post treatment HDL was significantly lower compared to pre treatment and control. Pre treatment LDL was significantly higher compared to post treatment and control. Pre treatment triglyceride was significantly higher compared to post treatment and control, pre treatment total cholesterol was significantly lower compared to post treatment and control. Certain lipids are increased while some are decreased with malaria infection/treatment, the rapidly growing malaria parasite requires large amounts of lipids for increase in surface area and volume of its internal membranes, certain serum lipid fractions may favour the onset and/or severity of malaria infection.

Keywords:
malaria parasite lipid profile and anti-malaria therapy

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References:

[1]	Das BS, Thurnham DI, Das DB: Plasma α-tocopherol, retinol, and carotenoids in children with falciparum malaria. Am J Clin Nutr, (1996) 64: 194-100.
[2]	Davis TME, Sturm M, Zhang YR, Spancer JL, Graham RM, Li GQ, Taylor RR: Platelet-activating factor and lipid metabolism in acute malaria. J Infect, (1993) 26: 279-285.
[3]	Mohanty S, Mishra SK, Das BS, Satpathy SK, Mohanty D, Patnaik JK, Bose TK: Altered plasma lipid pattern in falciparum malaria. Ann Trop Med Parasitol, (1992) 86: 601-606.
[4]	Kittl EM, Diridl G, Lenhart V, Neuwald C, Tomasits J, Pichler H, Bauer k: HDL-cholesterol as a sensitive diagnostic criterion in malaria. Wien Klin Wochenschr, (1992) 104: 21-24.
[5]	Faucher JF, Ngou-Milama E, Missinou MA, Ngomo R, Kombila M, Kremsner PG: The impact of malaria on common lipid parameters. Parasitol Res, (2002) 88:1040-1043.
[6]	Sibmooh, N., Yamanont, P., Krudsood, S., Leowattana, W., Brittenham, G., Looareesuwan, S.and Udomsangpetch, R.. Increased fluidity and oxidation of malarial lipoproteins: relation with severity and induction of endothelial expression of adhesion molecules. Lipids in Health and Disease. (2004) 3, 15.
[7]	Baptisa JL, Vervoort T, Vander SP, Wery M: Changes in plasma lipid levels as a function of Plasmodium falciparum infection in Sao Tome. Parasite, (1996) 3: 335-340.
[8]	Garba, I.H., Ubom, G.A. and Adelola, T.D.. Changes in serum lipid profile in adult patients presenting with acute, uncomplicated Falciparum. Journal of Malaria Research. (2004) 1 (3-4).
[9]	Oluba, O.M., Olusola, A.O., Eidangbe, G.O., Babatola, L.J. and Onyeneke, E.C.. Modulation of lipoprotein cholesterol levels in Plasmodium berghei malarial infection by crude aqueous extract of Ganoderma lucidum. Cholesterol, (2012) 6.
[10]	Veerapan Khovidhunkit, Min-sun Kin, Reaz A, Memon, Judy K Shigenaga, Arthur H Moser, Kanneth R, Fingold, Carl Grunfeld. The pathogenesis of atherosclerosis affects of infection and inflammation on lipid and lipoprotein metabolism, mechanism and consequences to the host. Journal of Research Vol.; (2004) 45: 1169-1196.
[11]	Sinnis P, Willow TE, Briones MR, Herz J, Nussenzweig V. Remnant lipoproteins inhibit malaria sporozoite invasion of hepatocytes. JEM; (1996) Vol. 184: 945-954.
[12]	Khovidhunkit V, Memon RA, Feingold KR, Grunfeld C. Infection and inflammation induced proatherogenic changes of lipoproteins. J Infect Dis; (2000) 181: 8462-8472.
[13]	Monica Cheesbrough. Discrete Laboratory Practice in Tropical Countries Part 1, Cambridge Second Editions. Published by Press Syndicate of the University of Cambridge, (2005) chp. 5, page 247 -258.
[14]	Chikezie, P.C and Okpara, R.T. Serum Lipid Profile and Hepatic Dysfunction in Moderate Plasmodium Falciparum Infection, Global Journal of Medical research Diseases Global Journal of Medical research Diseases (2013) Volume 13 Issue 4 Version 1.0 pg 14-20.
[15]	Djoumessi S: Serum lipids and lipoproteins during malaria infection. Pathol Biol, (1989) 37: 909-911.
[16]	Ogbodo, S. O., Ogah, O., Obu, H.A., Shu, E.N. and Afiukwa, C.. Lipid and lipoprotein levels in children with malaria parasitaemia. Current Pediatric Research. (2008) 12 (1 & 2), 12-17.
[17]	Nilsson-Ehle I, Nilsson-Ehle P: Changes in plasma lipoproteins in acute malaria. J Intern Med, (1990) 227: 151-155.
[18]	Memon RA, Staprans I, Noor M, Holleran WM, Uchida Y, Moser AH, Feingold KR, Grunfeld C: Infection and inflammation induce LDL oxidation in vivo. Arterioscler Thromb Vasc Biol, (2000) 20: 1536-1542.
[19]	Griffiths, M. J., Ndungu, F., Baird, K. L., Muller, D. P.R., Marsh, K. and Newton, C. R. J. C.. Oxidative stress and erythrocyte damage in Kenyan children with severe Plasmodium falciparum malaria. British Journal of Haematology (2001). 113, 486-491.
[20]	Akanbi, O.M., J.A. Badaki, O.Y. Adeniran and O.O. Olotu. Effect of blood group and demographic characteristics on malaria infection, oxidative stress and haemoglobin levels in South Western Nigeria. Afr. J. Microbiol. Res., (2010) 4: 877-880.
[21]	Zuk M, McKean KA. Sex differences in parasite infections: patterns and processes. Inter J Parasitol; (1996) 26: 1009-23.