False-negative IgA Anti-tissue Transglutaminase

Nada Boutrid^{1, 2,} , Hakim Rahmoune^{1, 2} and Mounira Amrane^{2, 3}

¹Department of Pediatrics, University Hospital of Setif; Setif 1 University, Algeria

²Genetic, Cardiovascular & Nutritional Diseases Laboratory; Setif-1 University, Algeria

³Central Laboratory, CAC Hospital of Setif; Setif-1 University, Algeria

Cite this paper:
Nada Boutrid, Hakim Rahmoune and Mounira Amrane. False-negative IgA Anti-tissue Transglutaminase. International Journal of Celiac Disease. 2018; 6(3):87-88. doi: 10.12691/ijcd-6-3-2

Abstract

The expanding knowledge about gluten-related autoimmunity led to a serology-based step-wised approach to diagnose celiac disease that might be misleading due to laboratory techniques. We present a rare case associating initial false-negative anti-transglutaminase IgA antibodies while CD was confirmed by IgG anti-transglutaminase and subsequent duodenal biopsy.

Keywords:
celiac disease autoimmunity immunoglobulin A tissue transglutaminase

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