The Gut Feeling of the Heart: Pathophysiological Pathways in the Gut-heart Axis in Celiac Disease

Aaron Lerner^1, and Jozélio Freire de Carvalho²

¹Chaim Sheba Medical Center, The Zabludowicz Research Center for Autoimmune Diseases, Tel Hashomer, Israel

²Institute for Health Sciences from Federal University of Bahia, Salvador, Bahia, Brazil

Cite this paper:
Aaron Lerner and Jozélio Freire de Carvalho. The Gut Feeling of the Heart: Pathophysiological Pathways in the Gut-heart Axis in Celiac Disease. International Journal of Celiac Disease. 2020; 8(4):120-123. doi: 10.12691/ijcd-8-4-2

Abstract

The chain of events, starting from nutrients that change microbiome/dysbiome ratio followed by their secreted mobilome and ending with the leaky gut syndrome, can be applied for cardiovascular diseases. The Gut-heart axis is only one avenue where intestinal luminal eco-events induce remote organ's pathology. The present editorial highlights the mechanisms and potential pathways in the nutrients-microbiota-endocrine-cardiovascular axis that might affect human heart morbidity and mortality in celiac disease.

Keywords:
celiac disease cardiovascular disease microbiome dysbiome metabolome nutrition gut-heart axis leaky gut nutritional deficiency

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