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American Journal of Educational Research
ISSN (Print): 2327-6126 ISSN (Online): 2327-6150 Website: https://www.sciepub.com/journal/education Editor-in-chief: Ratko Pavlović
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American Journal of Educational Research. 2020, 8(11), 828-846
DOI: 10.12691/education-8-11-3
Open AccessArticle

The Essence of Health and Longevity

Ivo P. Janecka1,

1Foundation for Systems Research and Education, New York, NY, US

Pub. Date: November 15, 2020
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Cite this paper:
Ivo P. Janecka. The Essence of Health and Longevity. American Journal of Educational Research. 2020; 8(11):828-846. doi: 10.12691/education-8-11-3

Abstract

The health of global societies is worsening; this is reflected not only in the increasing prevalence of co-morbidities in the population but also in already registered shortened lifespan. Systems science and the dynamic systems model have been used to study the core issues of unhealthy biologic systems, cascading down to cellular level. The still-evolving COVID-19 pandemic has exposed the vulnerabilities and spiraling penalties of unhealthy lifestyles. Dysfunctional immune system, a boundary, has been put in focus in this study, for its role in not only failing to protect but, through its components breakdown, also cause damage to the entire biologic system of human body; more than the ‘virus’, human decisions, and their impact on health, have been the significant upstream etiology of the pandemic because viruses favor unhealthy cells for their replication. The path to regain health, individually and collectively, is not in new drugs but in inculcating the importance of highly-structured decisions-consequences learning loop; in addition, interval training, spanning intensive physical exercise and selectivity of caloric and sensory input, benefits all levels of living systems-from cells to societies.

Keywords:
health longevity immunity decisions consequences hierarchies training

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References:

[1]  Abraham Lincoln. www.goodreads.com/quotes/5851097-and-in-the-end-it-s-not-the-years-in-your
 
[2]  Montapert, A. A, The Supreme Philosophy of Man: The Laws of Life, Prentice-Hall, 1977.
 
[3]  Peck, M.S, The Road Less Traveled, Simon & Schuster, Parsippany, NJ, 1985.
 
[4]  Von Bertalanffy, L. General System Theory: Foundations, Development, Applications, New York: George Braziller, 1969.
 
[5]  Hossenfelder, S, Looking in the Wrong Places - A Conversation With SABINE HOSSENFELDER, Frankfurt Institute for Advanced Studies, Edge #513, 4/30/18 https://www.edge.org/conversation/sabine_hossenfelder-looking-in-the-wrong-places.
 
[6]  Janecka, I.P, “Cancer control through principles of systems science, complexity, and chaos theory: A model”. Int J Med Sci, 4:164-173. 2007.
 
[7]  Zhou, B., Kreuzer, J., Kumsta, C., Wu, L., Kamer, K.J, et al. “Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension”, Cell, 177 (2). 299-314. March 2019.
 
[8]  Pascua-Maestro, R., Diez-Hermano, S., Lillo C, Ganfornina, M.D, Sanchez, D, “Protecting cells by protecting their vulnerable lysosomes: Identification of a new mechanism for preserving lysosomal functional integrity upon oxidative stress”. PLoS Genet, 13 (2). Feb 2017.
 
[9]  Schmitt, K., Grimm, A., Dallmann, R., Oettinghaus, B., Lisa Michelle Restelli, L.M., et al. “Circadian Control of DRP1 Activity Regulates Mitochondrial Dynamics and Bioenergetics”. Cell Metabolism, 2018.
 
[10]  Tam, B.T., Morais, J.A., Santosa. S, “Obesity and ageing: Two sides of the same coin”. Obesity Reviews, 2020.
 
[11]  Cheval, B., Orsholits, D., Sieber, S., Courvoisier, D., Cullati, S, et al. “Relationship between decline in cognitive resources and physical activity”. Health Psychology, 2020.
 
[12]  Janecka, I.P, “Sensory Processing and Systems Science: There Is More Than Meets the Eye”. Am J of Psychology and Cognitive Science, 1 (5). Dec 6, 2015.
 
[13]  Burtscher, J, “Run for your life: tweaking the weekly physical activity volume for longevity”. Brit J of Sports Med, 54 (13). 2019.
 
[14]  Firth, J., Stubbs, B., Vancampfort, D., Schuch, F., Lagopoulos, J, et al. “Effect of aerobic exercise on hippocampal volume in humans: A systematic review and meta-analysis”. NeuroImage, 166 (230). 2018.
 
[15]  de Lamarck, J.B.P.A, Philosophie zoologique: ou Exposition des considérations relative à l'histoire naturelle des animaux, 1809. Accessed Jun 2020.
 
[16]  de Cabo, R., Mattson, M.P., “Effects of Intermittent Fasting on Health, Aging, and Disease”. N Engl J Med, 381:2541-2551. 2019.
 
[17]  Wu, Z., Isik, M., Moroz, N., Steinbaugh, M.J., Zhang, P., Blackwell, T.K, “Dietary Restriction Extends Lifespan through Metabolic Regulation of Innate Immunity”. Cell Metabolism, 2019.
 
[18]  Anderson, R.M., Couteur, D.G., de Cabo, R, “Caloric Restriction Research: New Perspectives on the Biology of Aging”. The Journals of Gerontology: Series A, 73 (1). 2018.
 
[19]  Seidelmann, S.B., Claggett, B., Cheng, S., Henglin, M., Shah, B., et al. “Dietary carbohydrate intake and mortality: a prospective cohort study and meta-analysis”. The Lancet, 3 (9), E419-E428, 2018.
 
[20]  Kaelberer, M.M., Buchanan, K.L., Klein, M.E., Barth, B.B., Montoya, M.M., et al. “A gut-brain neural circuit for nutrient sensory transduction”. Science, 361 (6408): eaat5236, 2018.
 
[21]  Campbell, T.P., Sun, X., Patel, V.H., Sanz, C., Morgan, D., Dantas. G, “The microbiome and resistome of chimpanzees, gorillas, and humans across host lifestyle and geography”. ISME Journal, 2020.
 
[22]  van de Wijgert, J., H., M, “The vaginal microbiome and sexually transmitted infections are interlinked: Consequences for treatment and prevention”. PLoS Med 14(12): e1002478. 2017.
 
[23]  Cano-Gamez, E., Soskic, B., Roumeliotis, Ernest So, E., Smyth, D.J. et al. “Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4 T cells to cytokines”. Nature Communications, 11 (1). 2020.
 
[24]  Ref Gregg E. Dinse, G.E., Parks, C.G., Weinberg, C.R., et al. “Increasing prevalence of antinuclear antibodies in the United States”. Arthritis Rheumatol, 72:1026. 2020.
 
[25]  Reinhart, R.M.G., “Disruption and rescue of interareal theta phase coupling and adaptive behavior”. Proceedings of the National Academy of Sciences, 201710257. 2017.
 
[26]  Crawford, H. E. W, Sumer and the Sumerians, Cambridge University Press, Cambridge, 2004.
 
[27]  Herculano-Houzel. S, “Longevity and sexual maturity vary across species with number of cortical neurons, and humans are no exception”. Journal of Comparative Neurology, 2018.
 
[28]  Aggarwal-Schifellite, M, “Childhood trauma can speed biological aging”. Harvard Gazette, Aug 3, 2020. https://news.harvard.edu/gazette/story/2020/08/violence-and- trauma-in-childhood-accelerate- puberty/?utm_source=SilverpopMailing&utm_medium=email&ut m_campaign=Daily%20Gazette%2020200805%20(1)
 
[29]  Ouni, M., Saussenthaler, S., Eichelmann, F., Jähnert, M., Stadion,M., et al. “Epigenetic Changes in Islets of Langerhans Preceding the Onset of Diabetes”. Diabetes, db200204. 2020.
 
[30]  Tam, B.T., Morais, J.A., Santosa. S, “Obesity and ageing: Two sides of the same coin”. Obesity Reviews, 2020.
 
[31]  Sonnenschein, C., Soto, A.M, “Over a century of cancer research: Inconvenient truths and promising leads”. PLoS Biol 18(4): e3000670. 2020.
 
[32]  Popkin, B.M., Du, S., Green, W.D., Beck, M.A., Algaith, T., et al. “Individuals with obesity and COVID-19: A global perspective on the epidemiology and biological relationships”. Obesity Reviews, 2020.
 
[33]  Osman, M.S., van Eeden, C., Tervaert. J.W.C., “Fatal COVID-19 infections: Is NK cell dysfunction a link with autoimmune HLH?” Autoimmunity Reviews, 102561, 2020.
 
[34]  Daneshkhah, A., Agrawal, V., Eshein, A., Subramanian, H., Hemant Kumar Roy, H.K., Backman. V., “The Possible Role of Vitamin D in Suppressing Cytokine Storm and Associated Mortality in COVID-19 Patients”. medRxiv, Posted April 30, 2020.
 
[35]  Ilie, P.C., Stefanescu, S., Smith. L., “The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality”. Aging Clinical and Experimental Research, 32, 1195-1198, 2020.
 
[36]  CDC, “Hospitalization Rates and Characteristics of Patients Hospitalized with Laboratory-Confirmed Coronavirus Disease 2019 — COVID-NET, 14 States, March 1-30, 2020”, Apr 8, 2020. https://www.cdc.gov/mmwr/volumes/69/wr/mm6915e3.htm.
 
[37]  Patron, J., Serra-Cayuela, A., Han, B., Li, C., Wishart. D.S., “Assessing the performance of genome-wide association studies for predicting disease risk”. PLOS ONE, 14 (12): e0220215, 2019.
 
[38]  Ruby, J.G., Wright, K.M., Rand, K.A., Kermany, A., Noto, K., “Estimates of the Heritability of Human Longevity Are Substantially Inflated due to Assortative Mating”. Genetics, 210 (3): 1109, 2018.
 
[39]  Hale, J.M., Schneider, D.C., Gampe, J., Mehta, N.K., Myrsky, M., “Trends in the Risk of Cognitive Impairment in the United States, 1996-2014”. Epidemiology, 31 (5): 745, 2020.
 
[40]  Li, Y., Pan, A., Wang, D.D., Liu, X., Dhana, K., Franco, O.H., et al., “Impact of Healthy Lifestyle Factors on Life Expectancies in the US Population “, CIRCULATIONAHA.117.032047, 2018.
 
[41]  Hashimoto, K., Kouno, T., Ikawa, T., Hayatsu, N., Yurina, et al. “Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians”. Proceedings of the National Academy of Sciences, 201907883, 2019..
 
[42]  Perls, T., “Supercentenarians: How they live to over 110”, Oct 27, 2015. https://www.foxnews.com/health/supercentenarians-how-they-live-to-over-110.
 
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