Comparative Study of Propofol and Thiopentone Sodium as Intravenous Induction Agents in General Anaestetic Surgical Procedures in a Teaching Hospital

S. Vijaya¹, Basav Raj Munge², KK. Lakshmi Prasad³ and M. Prasad Naidu^4,

¹Department of Pharmacology, Rajiv Gandhi institute of Medical Sciences, Srikakulam, India

²Department of Pharmacology, Maharaja institute of Medical sciences, Vijayanagaram, India

³Department of Community Medicine, Gitam institute of Medical sciences and Research, Visakhapatnam, India

⁴Departmentof Biochemistry, Narayana Medical College and Hospital, Nellore, AP, India

Cite this paper:
S. Vijaya, Basav Raj Munge, KK. Lakshmi Prasad and M. Prasad Naidu. Comparative Study of Propofol and Thiopentone Sodium as Intravenous Induction Agents in General Anaestetic Surgical Procedures in a Teaching Hospital. American Journal of Pharmacological Sciences. 2015; 3(3):52-54. doi: 10.12691/ajps-3-3-1

Abstract

Thiopentone and propofol are the intravenous induction anaesthetic agents used during general surgery. The study was done with an aim to compare the intra operative and the Post operative findings in Propofol and Thiopentone groups. The study was conducted in 100 adult patients of ASA grade 1 and grade II of aged between 18- 60 yrs of both sexes who were posted for different types of Surgical Procedures in department of anaesthesiology, General Hospital, RIMS, Srikakulam from January 2013 to October 2013. The intra-operative findings like Pulse rate, blood pressure and oxygen saturation were measured in both groups and no significance difference was observed for pulse rate and oxygen saturation except for Blood pressure. Post operative findings especially response time and Orientation time was less in patients receiving Propofol when compared with Thiopentone group which is highly significant. Incidence of nausea, headache and shivering were more with thiopentone sodium than with propofol. In this study we concluded that propofol is better alternative to thiopentone sodium as main anaesthetic agent for general surgical procedures with less side effects.

Keywords:
propofol thiopentone anaesthetic agent and general surgical procedures

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References:

[1]	Noam Nahum Douglas Butterfield. “General Anesthesia and Cognitive Impairment”. The University of British Columbia, 2003:16-18.
[2]	Gillick, Muriel, R. “The denial of aging: Perpetual youth, eternal life, and other dangerous fantasies”. Harvard University Press, 2009.
[3]	Rego, Monica M. Sa, Mehernoor F., Watcha and Paul, F. White. “The changing role of monitored anesthesia care in the ambulatory setting.” Anesthesia & Analgesia 85.5 (1997): 1020-1036.
[4]	Gogolak, G., F. Krijzer. , and Ch Stumpf. “Action of central depressant drugs on the electrocerebellogram of the rabbit.” Naunyn-Schmiedeberg's archives of pharmacology 272.4 (1972): 378-386.
[5]	La Harpe, De., and Charl Jacques. A comparison of the efficacy and safety of intranasal sufentanil/midazolam and ketamine/midazolam for sedation and analgesia in a paediatric population undergoing multiple dental extractions. 2005.
[6]	López-Muñoz, Francisco, Ronaldo Ucha-Udabe, and Cecilio Alamo. “The history of barbiturates a century after their clinical introduction.” Neuropsychiatric disease and treatment 1.4 (2005): 329.
[7]	Roncagli, G., and Gordon M. Wyant. “Studies Of Changes In Renal Hemodynamics During General Anesthesia.” Survey of Anesthesiology 2.6 (1958): 620-631.
[8]	Alston, R. Peter. “An history of cardiothoracic anaesthesia.” Oxford Textbook of Cardiothoracic Anaesthesia (2015): 1.
[9]	Francisco López-Muñoz, Ronaldo Ucha-Udabe, and Cecilio. “History of barbiturates a century after their clinical introduction”. Alamo Neuropsychiatr Dis Treat. 2005 December; 1(4): 329-343.
[10]	Gelderblom, Hans, et al. “Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation.” European Journal of Cancer 37.13 (2001): 1590-1598.
[11]	Hall, Michael A., et al. “m-Azipropofol (AziP m) a Photoactive Analogue of the Intravenous General Anesthetic Propofol.” Journal of medicinal chemistry 53.15 (2010): 5667-5675.
[12]	Yang, C. Y., et al. “Hemodynamic responses of thiopental and propofol in different-aged patients during endotracheal intubation.” Chang Gung medical journal 24.6 (2001): 376-382.
[13]	Djordjević B, Stojiljković MP, Loncar-Stojiljković D, Krivokapić D, Adamov A. “Adverse effects reported after inductive doses of the intravenous anesthetics, thiopentone, etomidate and propofol”. Vojnosanit Pregl. 1999 Mar-Apr;56(2):143-50.
[14]	Kashtan H, Edelist G, Mallon J, Kapala D. “Comparative evaluation of propofol and thiopentone for total intravenous anaesthesia”. Can J Anaesth. 1990 Mar;37(2):170-6.
[15]	Klockgether-Radke, A., et al. “Nausea and vomiting after laparoscopic surgery: a comparison of propofol and thiopentone/halothane anaesthesia.” European Journal of Anaesthesiology (EJA) 13.1 (1996): 3-9.
[16]	Cheong, K F., Chen F G., and Yau G H M. “Postanaesthetic shivering-a comparison of thiopentone and propofol.” ANNALS-ACADEMY OF MEDICINE SINGAPORE 27 (1998): 729-732.
[17]	Runcie CJ, Mackenzie SJ, Arthur DS, Morton NS et al. “Comparison of recovery from anaesthesia induced in children with either propofol or thiopentone.” British journal of anaesthesia 70.2 (1993): 192-195.