1Department of Pharmacology, Rajiv Gandhi institute of Medical Sciences, Srikakulam, India
2Department of Pharmacology, Maharaja institute of Medical sciences, Vijayanagaram, India
3Department of Community Medicine, Gitam institute of Medical sciences and Research, Visakhapatnam, India
4Departmentof Biochemistry, Narayana Medical College and Hospital, Nellore, AP, India
American Journal of Pharmacological Sciences.
2015,
Vol. 3 No. 3, 52-54
DOI: 10.12691/ajps-3-3-1
Copyright © 2015 Science and Education PublishingCite this paper: S. Vijaya, Basav Raj Munge, KK. Lakshmi Prasad, M. Prasad Naidu. Comparative Study of Propofol and Thiopentone Sodium as Intravenous Induction Agents in General Anaestetic Surgical Procedures in a Teaching Hospital.
American Journal of Pharmacological Sciences. 2015; 3(3):52-54. doi: 10.12691/ajps-3-3-1.
Correspondence to: M. Prasad Naidu, Departmentof Biochemistry, Narayana Medical College and Hospital, Nellore, AP, India. Email:
m.prasadnaidu@ymail.comAbstract
Thiopentone and propofol are the intravenous induction anaesthetic agents used during general surgery. The study was done with an aim to compare the intra operative and the Post operative findings in Propofol and Thiopentone groups. The study was conducted in 100 adult patients of ASA grade 1 and grade II of aged between 18- 60 yrs of both sexes who were posted for different types of Surgical Procedures in department of anaesthesiology, General Hospital, RIMS, Srikakulam from January 2013 to October 2013. The intra-operative findings like Pulse rate, blood pressure and oxygen saturation were measured in both groups and no significance difference was observed for pulse rate and oxygen saturation except for Blood pressure. Post operative findings especially response time and Orientation time was less in patients receiving Propofol when compared with Thiopentone group which is highly significant. Incidence of nausea, headache and shivering were more with thiopentone sodium than with propofol. In this study we concluded that propofol is better alternative to thiopentone sodium as main anaesthetic agent for general surgical procedures with less side effects.
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